Phenotypes associated with this allele

• Allele Symbol: Mims1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5605775
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mims1^tm1b(EUCOMM)Wtsi/Mims1^tm1b(EUCOMM)Wtsi	involves: BALB/cJ * C57BL/6N	MGI:6159283
ht2	Mims1^tm1b(EUCOMM)Wtsi/Mims1^+	involves: BALB/cJ * C57BL/6N	MGI:6159282

Genotype
MGI:6159283

hm1

• Allelic Composition: Mims1^{tm1b(EUCOMM)Wtsi}/Mims1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: involves: BALB/cJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:261817 )

• mice died shortly after E9.5

Genotype
MGI:6159282

ht2

• Allelic Composition: Mims1^{tm1b(EUCOMM)Wtsi}/Mims1⁺
• Genetic Background: involves: BALB/cJ * C57BL/6N

skeleton

increased osteoclast cell number ( J:261817 )

decreased bone mineral density ( J:261817 )

• in cortical bones

abnormal compact bone morphology ( J:261817 )

• mice exhibit increased cortical porosity compared with control mice

decreased compact bone volume ( J:261817 )

decreased compact bone thickness ( J:261817 )

decreased bone ossification ( J:261817 )

• in cortical bones

decreased bone strength ( J:261817 )

immune system

increased osteoclast cell number ( J:261817 )

hematopoietic system

increased osteoclast cell number ( J:261817 )