Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}
• Allele Name: targeted mutation 1, Zhengui Xia
• Allele ID: MGI:5605718
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm1(ACTB-Map2k5*/EGFP)Zxi/Gt(ROSA)26Sor^tm1(ACTB-Map2k5*/EGFP)Zxi Tg(Nes-cre/Esr1*)4Ynj/0	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5605719
cn2	Gt(ROSA)26Sor^tm1(ACTB-Map2k5*/EGFP)Zxi/Gt(ROSA)26Sor^tm14(CAG-tdTomato)Hze Tg(Nes-cre/Esr1*)4Ynj/0	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5605720

Genotype
MGI:5605719

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}/Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}; Tg(Nes-cre/Esr1*)4Ynj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal dentate gyrus morphology ( J:206948 )

• increase in the number of DCX+ cells 2 weeks after tamoxifen treatment

• increase in the number of adult born mature neurons in mice dosed with tamoxifen for 7 days and perfused 7.5 weeks after the last dose of tamoxifen

abnormal neuron physiology ( J:206948 )

• increase in survival of neurons in the dentate gyrus in tamoxifen treated mice

behavior/neurological

enhanced long-term object recognition memory ( J:206948 )

• enhanced retention of familiar object memory (at 24 and 48h after training) in tamoxifen treated mice

• enhanced retention of a memory for an object in a familiar location (at 48h after training) in tamoxifen treated mice

enhanced spatial learning ( J:206948 )

• in tamoxifen treated mice in a Morris water maze

abnormal spatial reference memory ( J:206948 )

• enhanced memory formation in tamoxifen treated mice in a Morris water maze

abnormal long-term spatial reference memory ( J:206948 )

• extended long-term spatial memory (retain strong spatial memory on days 37 and 51) in tamoxifen treated mice in a Morris water maze

Genotype
MGI:5605720

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(ACTB-Map2k5*/EGFP)Zxi}/Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}; Tg(Nes-cre/Esr1*)4Ynj/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

nervous system

nervous system phenotype ( J:206948 )

N • no change in the volume of the granule cell layer in the dentate gyrus or in the number of radial glia-like adult neural stem cells indicating no affect on the adult neural stem cell pool

abnormal dentate gyrus morphology ( J:206948 )

• increase in the number of NeuN+ neurons in tamoxifen treated mice at 3 weeks and 7 weeks of age

abnormal dendrite morphology ( J:206948 )

• average primary dendritic length and number of dendritic crossings are increased in the dentate gyrus in tamoxifen treated mice

abnormal dendritic spine morphology ( J:206948 )

• increase in spine density in the dentate gyrus in tamoxifen treated mice