Phenotypes associated with this allele

• Allele Symbol: Tspo^tm1.1Guwu
• Allele Name: targeted mutation 1.1, Richard Banati
• Allele ID: MGI:5603424
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspo^tm1.1Guwu/Tspo^tm1.1Guwu	involves: C57BL/6	MGI:5750127

Genotype
MGI:5750127

hm1

• Allelic Composition: Tspo^tm1.1Guwu/Tspo^tm1.1Guwu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitochondrial ATP synthesis coupled electron transport ( J:219189 )

• significantly reduced ATP production by mitochondria

hematopoietic system

hematopoietic system phenotype ( J:219189 )

N • most cellular blood components are normal

increased NK cell number ( J:219189 )

♀ • increased natural killer cell numbers in females

reproductive system

reproductive system phenotype ( J:219189 )

N • mice are viable

N • sex ratio normal

N • fertility and sperm viability both normal

N • litter size normal

behavior/neurological

behavior/neurological phenotype ( J:219189 )

N • open field, light/dark preference, elevated plus maze tests all normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:219189 )

N • no clinical impairment on a normal diet

N • no increase in incidental pathologies

growth/size/body

growth/size/body region phenotype ( J:219189 )

N • length of 1 day old pups is normal

N • growth rate normal

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:219189 )

N • cholesterol to pregnenolone biosynthesis normal

N • serum levels normal

mortality/aging

mortality/aging ( J:219189 )

N • life span normal

immune system

increased NK cell number ( J:219189 )

♀ • increased natural killer cell numbers in females