Phenotypes associated with this allele

• Allele Symbol: Mrpl22^{tm1b(KOMP)Mbp}
• Allele Name: targeted mutation 1b, Mouse Biology Program, UC Davis
• Allele ID: MGI:5603347
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrpl22^tm1b(KOMP)Mbp/Mrpl22^tm1b(KOMP)Mbp	B6N(Cg)-Mrpl22^tm1b(KOMP)Mbp/J	MGI:6370162
hm2	Mrpl22^tm1b(KOMP)Mbp/Mrpl22^tm1b(KOMP)Mbp	C57BL/6N-Mrpl22^tm1b(KOMP)Mbp/J	MGI:6262918
ht3	Mrpl22^tm1b(KOMP)Mbp/Mrpl22^+	C57BL/6N-Mrpl22^tm1b(KOMP)Mbp/J	MGI:5888398

Genotype
MGI:6370162

hm1

• Allelic Composition: Mrpl22^{tm1b(KOMP)Mbp}/Mrpl22^{tm1b(KOMP)Mbp}
• Genetic Background: B6N(Cg)-Mrpl22^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD0007_6_E07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to organogenesis ( J:279207 )

• homozygous embryos are recovered at expected Mendelian ratios at E7.5 but arrest prior to gastrulation

embryonic lethality, complete penetrance ( J:279207 )

• no homozygous embryos are recovered at E9.5

embryo

failure to gastrulate ( J:279207 )

• no hallmarks typical of gastrulating embryos are observed at E7.5

embryonic growth arrest ( J:279207 )

• embryos arrest prior to gastrulation

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

abnormal egg cylinder morphology ( J:279207 )

• a rudimentary egg cylinder is observed at E7.5

absent head fold ( J:279207 )

• no head folds are present at E7.5

absent primitive node ( J:279207 )

• no embryonic node is present at E7.5

failure of primitive streak formation ( J:279207 )

• no morphological evidence of primitive streak formation is observed at E7.5

growth/size/body

decreased embryo size ( J:279207 )

• embryos are much smaller than controls at E7.5

Genotype
MGI:6262918

hm2

• Allelic Composition: Mrpl22^{tm1b(KOMP)Mbp}/Mrpl22^{tm1b(KOMP)Mbp}
• Genetic Background: C57BL/6N-Mrpl22^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD0007_6_E07

Data Sources

IMPC Data for Mrpl22

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5888398

ht3

• Allelic Composition: Mrpl22^{tm1b(KOMP)Mbp}/Mrpl22⁺
• Genetic Background: C57BL/6N-Mrpl22^{tm1b(KOMP)Mbp}/J
• Cell Lines: DEPD0007_6_E07

Data Sources

IMPC Data for Mrpl22

behavior/neurological

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

♀

IMPC - JAX

vision/eye

impaired pupillary reflex ( J:211773 )

♂

IMPC - JAX