Phenotypes associated with this allele

• Allele Symbol: Lyn^M1Btlr
• Allele Name: mutation 1, Bruce Beutler
• Allele ID: MGI:5603319
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyn^M1Btlr/Lyn^M1Btlr	C57BL/6J-Lyn^M1Btlr	MGI:5603320
ht2	Lyn^M1Btlr/Lyn^+	C57BL/6J-Lyn^M1Btlr	MGI:5603321

Genotype
MGI:5603320

hm1

• Allelic Composition: Lyn^M1Btlr/Lyn^M1Btlr
• Genetic Background: C57BL/6J-Lyn^M1Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice homozygous for this mutation are greater than in the blood of heterozyggous mutant or wild-type control mice

decreased B cell number ( J:214511 )

• B lymphocyte frequencies in the peripheral blood of mice homozygous for this mutation are lower than in the blood of heterozygous mutant or wild-type control mice

• proportions of IgM⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or wild-type mice.

• proportions of IgD⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or control mice.

immune system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice homozygous for this mutation are greater than in the blood of heterozyggous mutant or wild-type control mice

decreased B cell number ( J:214511 )

• B lymphocyte frequencies in the peripheral blood of mice homozygous for this mutation are lower than in the blood of heterozygous mutant or wild-type control mice

• proportions of IgM⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or wild-type mice.

• proportions of IgD⁺ B cells in the peripheral blood of homozygous mutant mice are lower than in heterozygous or control mice.

Genotype
MGI:5603321

ht2

• Allelic Composition: Lyn^M1Btlr/Lyn⁺
• Genetic Background: C57BL/6J-Lyn^M1Btlr

hematopoietic system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those of homozygous mutant and wild-type control mice

decreased B cell number ( J:214511 )

• B cell frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those in the blood of homozygous mutant and wild-type control mice

• proportions of peripheral blood IgM⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

• proportions of peripheral blood IgD⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

immune system

increased neutrophil cell number ( J:214511 )

• neutrophil frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those of homozygous mutant and wild-type control mice

decreased B cell number ( J:214511 )

• B cell frequencies in the peripheral blood of mice heterozygous for this mutation are intermediate between those in the blood of homozygous mutant and wild-type control mice

• proportions of peripheral blood IgM⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice

• proportions of peripheral blood IgD⁺ B cells in heterozygous mutant mice are intermediate between those in homozygous and wild-type mice