Phenotypes associated with this allele

• Allele Symbol: Ano1^tm1.1Cahb
• Allele Name: targeted mutation 1.1, Christian Hubner
• Allele ID: MGI:5588146
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ano1^tm1.1Cahb/Ano1^tm1.1Cahb Tg(Myh11-icre/ERT2)1Soff/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5588166

Genotype
MGI:5588166

cn1

• Allelic Composition: Ano1^tm1.1Cahb/Ano1^tm1.1Cahb; Tg(Myh11-icre/ERT2)1Soff/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:207993 )

N • tamoxifen-treated mice exhibit normal cardiac parameters (fractional shortening, cardiac output, ejection fraction, and heart rate)

abnormal pericyte morphology ( J:207993 )

• absent calcium-activated chloride currents in pericytes of small arterioles from brain, retina, skeletal muscle and skin of tamoxifen-treated mice

• almost absent U46619-induced depolarization in pericytes of tamoxifen-treated mice despite pericyte hyperpolarization after agonist application without a further increase upon replacement of chloride with methanesulfonate

abnormal vascular smooth muscle morphology ( J:207993 )

• vascular smooth muscle cells lack calcium-activated chloride currents in tamoxifen-treated mice

abnormal systemic arterial blood pressure ( J:207993 )

• decreased pressure amplitude in tamoxifen-treated mice

decreased mean systemic arterial blood pressure ( J:207993 )

• in tamoxifen-treated mice and more so in the presence of angiotensin II

• low-salt diet does not further decrease blood pressure

• however, systemic blood pressure differences are eliminated on a high-salt diet

abnormal blood vessel physiology ( J:207993 )

• reduced brain and retina small arteriole contractility in tamoxifen-treated mice

decreased vasoconstriction ( J:207993 )

• reduced vascular smooth muscle cell contractility in the aorta of tamoxifen-treated mice

• however, contractility in mesenteric arteries is normal

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:207993 )

N • tamoxifen-treated mice exhibit normal plasma aldosterone, renin, angiotensin II, potassium and various blood gas parameters

N • tamoxifen-treated mice exhibit normal creatinine clearance and fractional excretion of sodium, chloride and potassium

muscle

abnormal vascular smooth muscle morphology ( J:207993 )

• vascular smooth muscle cells lack calcium-activated chloride currents in tamoxifen-treated mice

decreased vasoconstriction ( J:207993 )

• reduced vascular smooth muscle cell contractility in the aorta of tamoxifen-treated mice

• however, contractility in mesenteric arteries is normal