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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gba1tm2.1Eginn
targeted mutation 2.1, Edward I Ginns
MGI:5587918
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gba1tm2.1Eginn/Gba1tm2.1Eginn involves: 129X1/SvJ * C57BL/6 MGI:5587928


Genotype
MGI:5587928
hm1
Allelic
Composition		 Gba1tm2.1Eginn/Gba1tm2.1Eginn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gba1tm2.1Eginn mutation (1 available); any Gba1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal spleen enzyme/coenzyme activity ( J:211953 )
• 13% lower enzymatic activity in spleen compared to controls
decreased liver enzyme/coenzyme activity ( J:211953 )
• 35% lower enzymatic activity in liver compared to controls

hematopoietic system
abnormal spleen enzyme/coenzyme activity ( J:211953 )
• 13% lower enzymatic activity in spleen compared to controls

nervous system
astrocytosis ( J:211953 )
• in striatum at 1 year of age
abnormal striatum morphology ( J:211953 )
• astrocytosis and alpha-synuclein accumulation in striatum at 1 year of age
alpha-synuclein inclusion body ( J:211953 )
• in striatum at 1 year of age

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:211953 )
• 35% lower enzymatic activity in liver compared to controls

cellular
astrocytosis ( J:211953 )
• in striatum at 1 year of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory