Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
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mortality/aging
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• fewer (10%) than the expected (25%) numbers of adult homozygotes are seen
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• perinatal lethality is seen in about 50% of newborns
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nervous system
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• newborn and adult mice show reduced concentrations of murine amyloid beta40 and amyloid beta42 peptides
• however, concentration of the soluble APP alpha is not affected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
|
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nervous system
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• mice show reduced concentrations of murine amyloid beta40 and amyloid beta42 peptides
• however, concentration of the soluble murine APP alpha is not affected
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm3.1(CAG-SORL1)Tew mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(APPV717F)109Ili mutation
(0 available)
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nervous system
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• mice show reduced concentrations of human amyloid beta40 and amyloid beta42 peptides in cortical and hippocampal extracts
• however, basal concentrations of brain interstitial fluid amyloid beta40 are unchanged in the brain parenchyma of adults compared to single Tg(APPV717F)109Ili mice
• concentrations of the soluble human APP alpha and APP beta are not affected
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Analysis Tools