Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}
• Allele Name: targeted mutation 2, Tadahiro Kitamura
• Allele ID: MGI:5586719
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^tm2(Sirt1)Ktm/Gt(ROSA)26Sor^+ Tg(Pomc1-cre)16Lowl/0	involves: 129 * C57BL/6J * FVB/N	MGI:5586726
cn2	Gt(ROSA)26Sor^tm2(Sirt1)Ktm/Gt(ROSA)26Sor^+ Tg(Agrp-cre)1Gsb/0	involves: 129 * C57BL/6J * FVB/N	MGI:5586727

Genotype
MGI:5586726

cn1

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}/Gt(ROSA)26Sor⁺; Tg(Pomc1-cre)16Lowl/0
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

adipose tissue phenotype ( J:209418 )

N • mice fed normal chow exhibit normal epididymal white adipose tissue weight

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N • mice fed normal chow exhibit normal food intake and locomotor activity

growth/size/body

growth/size/body region phenotype ( J:209418 )

N • mice fed normal chow exhibit normal susceptibility to age-associated weight gain and body length

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N • mice fed normal chow exhibit normal oxygen consumption

Genotype
MGI:5586727

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm2(Sirt1)Ktm}/Gt(ROSA)26Sor⁺; Tg(Agrp-cre)1Gsb/0
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

adipose tissue

adipose tissue phenotype ( J:209418 )

N • mice fed normal chow exhibit normal epididymal white adipose tissue weight

behavior/neurological

behavior/neurological phenotype ( J:209418 )

N • mice fed normal chow exhibit normal food intake and locomotor activity

growth/size/body

growth/size/body region phenotype ( J:209418 )

N • mice fed normal chow exhibit normal susceptibility to age-associated weight gain and body length

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209418 )

N • mice fed normal chow exhibit normal oxygen consumption and rectal temperature