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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Oprm1tm1.1Jbwa
targeted mutation 1.1, Jia Bei Wang
MGI:5586574
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Oprm1tm1.1Jbwa/Oprm1tm1.1Jbwa involves: 129S6/SvEvTac * C57BL/6 MGI:5586653


Genotype
MGI:5586653
hm1
Allelic
Composition		 Oprm1tm1.1Jbwa/Oprm1tm1.1Jbwa
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oprm1tm1.1Jbwa mutation (1 available); any Oprm1 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
enhanced behavioral response to addictive substance ( J:101977 )
• mice exhibit attenuated opioid tolerance and enhanced opioid withdrawal
• mice exhibit enhanced vulnerability to heroin self-administration




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory