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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Col1a1tm2(tetO-Fosl2,-DsRed)Wag
targeted mutation 2, Erwin F Wagner
MGI:5585642
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129S4/SvJae * C57BL/6 * CD-1 MGI:5586499
cx2
Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+
Tg(Cebpb-tTA)5Bjd/0
involves: 129S4/SvJae * C57BL/6 * NMRI MGI:5586504


Genotype
MGI:5586499
cx1
Allelic
Composition
Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-Fosl2,-DsRed)Wag mutation (0 available); any Col1a1 mutation (160 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

skeleton
• decreased osteoclast surface
• increased osteoblast surface
• increased bone formation

homeostasis/metabolism
• in response to glucose stimulation
• in the pancreas
• in mice fed a normal diet or a high fat diet
• however, infection with Adipoq-expressing adenovirus rescues serum glucose levels in mice fed a normal or high fat diet
• in fasted mice fed a normal diet
• in mice fed a normal diet or a high fat diet
• however, bone insulin levels are normal and infection with Adipoq-expressing adenovirus rescues levels in mice fed a normal, but not high fat, diet
• in mice fed a normal diet or high fat diet
• however, infection with Adipoq-expressing adenovirus restores glucose tolerance in mice fed a normal diet
• in mice fed a normal diet or high fat diet
• however, infection with Adipoq-expressing adenovirus restores insulin sensitivity in mice fed a normal diet

growth/size/body
• under normal diet and high fat diet conditions
• however, infection with Adipoq-expressing adenovirus rescues body weight in mice fed a normal, but not high fat, diet

endocrine/exocrine glands
• in response to glucose stimulation
• in the pancreas

adipose tissue
N
• mice exhibit normal adipocyte number and size
• under normal diet and high fat diet conditions
• however, infection with Adipoq-expressing adenovirus rescues fat pad weight in mice fed a normal or high fat diet

hematopoietic system
• decreased osteoclast surface

immune system
• decreased osteoclast surface




Genotype
MGI:5586504
cx2
Allelic
Composition
Col1a1tm2(tetO-Fosl2,-DsRed)Wag/Col1a1+
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-Fosl2,-DsRed)Wag mutation (0 available); any Col1a1 mutation (160 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• compared with control mice when fed a high fat diet
• mice fed a high fat diet do not develop steatohepatitis unlike control mice

homeostasis/metabolism
N
• mice subjected to acetaminophen-induced hepatotoxicity exhibit a normal response
• compared with control mice when fed a high fat diet





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory