About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad7tm1Gkh
targeted mutation 1, Goran K Hansson
MGI:5585420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad7tm1Gkh/Smad7tm1Gkh B6N.129S6-Smad7tm1Gkh MGI:5585428
cn2
 		Smad7tm1Gkh/Smad7tm1Gkh
Tg(Cd4-cre)1Cwi/0 		B6N.Cg-Tg(CD4-cre)1Cwi Smad7tm1Gkh MGI:5585429


Genotype
MGI:5585428
hm1
Allelic
Composition		 Smad7tm1Gkh/Smad7tm1Gkh
Genetic
Background		 B6N.129S6-Smad7tm1Gkh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1Gkh mutation (0 available); any Smad7 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:213468 )
• mice exhibit normal growth and behavior without any signs of infection




Genotype
MGI:5585429
cn2
Allelic
Composition		 Smad7tm1Gkh/Smad7tm1Gkh
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6N.Cg-Tg(CD4-cre)1Cwi Smad7tm1Gkh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1Gkh mutation (0 available); any Smad7 mutation (53 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:213468 )
• bone marrow cells transplanted in Ldlrtm1Her leads to large atherosclerotic lesions with expended fibrous caps and deviation toward TH17
• however, IL17A neutralization prevents fibrous cap expansion




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory