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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Smad7tm1Gkh
targeted mutation 1, Goran K Hansson
MGI:5585420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Smad7tm1Gkh/Smad7tm1Gkh B6N.129S6-Smad7tm1Gkh MGI:5585428
cn2
 		Smad7tm1Gkh/Smad7tm1Gkh
Tg(Cd4-cre)1Cwi/0 		B6N.Cg-Tg(CD4-cre)1Cwi Smad7tm1Gkh MGI:5585429


Genotype
MGI:5585428
hm1
Allelic
Composition		 Smad7tm1Gkh/Smad7tm1Gkh
Genetic
Background		 B6N.129S6-Smad7tm1Gkh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1Gkh mutation (0 available); any Smad7 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:213468 )
• mice exhibit normal growth and behavior without any signs of infection




Genotype
MGI:5585429
cn2
Allelic
Composition		 Smad7tm1Gkh/Smad7tm1Gkh
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 B6N.Cg-Tg(CD4-cre)1Cwi Smad7tm1Gkh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad7tm1Gkh mutation (0 available); any Smad7 mutation (55 available)
Tg(Cd4-cre)1Cwi mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal bone marrow cell physiology ( J:213468 )
• bone marrow cells transplanted in Ldlrtm1Her leads to large atherosclerotic lesions with expended fibrous caps and deviation toward TH17
• however, IL17A neutralization prevents fibrous cap expansion




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory