Phenotypes associated with this allele

• Allele Symbol: Gcm2^tm1.2Malx
• Allele Name: targeted mutation 1.2, Michael Levine
• Allele ID: MGI:5584282
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gcm2^tm1.2Malx/Gcm2^tm1.2Malx	involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N	MGI:5584283

Genotype
MGI:5584283

hm1

• Allelic Composition: Gcm2^tm1.2Malx/Gcm2^tm1.2Malx
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating parathyroid hormone level ( J:213334 )

• serum levels of parathyroid hormone are undetectable in 16 of 23 mice and very low in 7 of 23 mice

decreased circulating calcium level ( J:213334 )

increased circulating phosphate level ( J:213334 )

mortality/aging

lethality, incomplete penetrance ( J:213334 )

• 30% lethality, however, surviving mice are similar in weight and length to controls from weaning to 20 months of age

endocrine/exocrine glands

parathyroid hypoplasia ( J:213334 )

• parathyroid tissue is decreased in size as compared to controls