Phenotypes associated with this allele

• Allele Symbol: Ninj1^tm1Gto
• Allele Name: targeted mutation 1, Goo Taeg Oh
• Allele ID: MGI:5583960
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ninj1^tm1Gto/Ninj1^tm1Gto	B6.129P2-Ninj1^tm1Gto	MGI:5583997
ht2	Ninj1^tm1Gto/Ninj1^+	B6.129P2-Ninj1^tm1Gto	MGI:5583999

Genotype
MGI:5583997

hm1

• Allelic Composition: Ninj1^tm1Gto/Ninj1^tm1Gto
• Genetic Background: B6.129P2-Ninj1^tm1Gto

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ninj1^tm1Gto/Ninj1^tm1Gto mice have reduced leukocyte recruitment into the spinal cord injury with experimental autoimmune encephalomyelitis

immune system

abnormal leukocyte physiology ( J:209516 )

• MOG35-55 immunized mice exhibit reduced recruitment of leukocytes into the lesion sites of the spinal cord compared with wild-type mice

impaired macrophage chemotaxis ( J:209516 )

• bone marrow derived macrophages exhibit reduced transendothelial migration compared with wild-type cells

abnormal leukocyte adhesion ( J:209516 )

• in a endotoxin-induced uveitis model, leukocytes exhibit reduced attachment to vessel walls of the retina compared to in wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:209516 )

• MOG35-55 immunized mice exhibit reduced clinical score and recruitment of leukocytes into the lesion sites of the spinal cord compared with wild-type mice

• however, mice exhibit weak limb paralysis

nervous system

hydrocephaly ( J:209516 )

• in some mice

behavior/neurological

ataxia ( J:209516 )

• in some mice

growth/size/body

postnatal growth retardation ( J:209516 )

• in some mice

cellular

impaired macrophage chemotaxis ( J:209516 )

• bone marrow derived macrophages exhibit reduced transendothelial migration compared with wild-type cells

abnormal leukocyte adhesion ( J:209516 )

• in a endotoxin-induced uveitis model, leukocytes exhibit reduced attachment to vessel walls of the retina compared to in wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:209516 )

N • untreated and MOG35-55-treated mice exhibit normal hemograms

abnormal leukocyte physiology ( J:209516 )

• MOG35-55 immunized mice exhibit reduced recruitment of leukocytes into the lesion sites of the spinal cord compared with wild-type mice

impaired macrophage chemotaxis ( J:209516 )

• bone marrow derived macrophages exhibit reduced transendothelial migration compared with wild-type cells

abnormal leukocyte adhesion ( J:209516 )

• in a endotoxin-induced uveitis model, leukocytes exhibit reduced attachment to vessel walls of the retina compared to in wild-type mice

Genotype
MGI:5583999

ht2

• Allelic Composition: Ninj1^tm1Gto/Ninj1⁺
• Genetic Background: B6.129P2-Ninj1^tm1Gto

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:209516 )

• MOG35-55 immunized mice exhibit reduced clinical score compared with wild-type mice