Phenotypes associated with this allele

• Allele Symbol: Ifi204^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5583087
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifi204^tm1b(KOMP)Wtsi/Ifi204^tm1b(KOMP)Wtsi	C57BL/6N-Ifi204^tm1b(KOMP)Wtsi/Ucd	MGI:5767689
hm2	Ifi204^tm1b(KOMP)Wtsi/Ifi204^tm1b(KOMP)Wtsi	involves: BALB/cJ * C57BL/6J * C57BL/6N	MGI:7863500

Genotype
MGI:5767689

hm1

• Allelic Composition: Ifi204^{tm1b(KOMP)Wtsi}/Ifi204^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Ifi204^{tm1b(KOMP)Wtsi}/Ucd
• Cell Lines: EPD0813_4_E07

Data Sources

IMPC Data for Ifi204

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

enlarged heart ( J:211773 )

♂

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♂

IMPC - UCD

Genotype
MGI:7863500

hm2

• Allelic Composition: Ifi204^{tm1b(KOMP)Wtsi}/Ifi204^{tm1b(KOMP)Wtsi}
• Genetic Background: involves: BALB/cJ * C57BL/6J * C57BL/6N
• Cell Lines: EPD0813_4_E07

immune system

immune system phenotype ( J:354143 )

N • newborn pups i.p. injected with wild-type Moloney murine leukemia virus (MLV) show no significant difference in splenic viral titers at 16 dpi relative to similarly infected wild-type controls

N • primary bone marrow-derived macrophages (BMDMs) infected by S. aureus or by K. pneumoniae show normal mRNA expression of Tnf (tumor necrosis factor) and Ifnb1 interferon beta 1, fibroblast) relative to similarly infected wild-type BMDMs, indicating a normal response to bacterial infection

N • after s.c. injection of LPS, mice show a marked induction of Tnf mRNA levels in the draining lymph nodes, similar to that in LPS-injected wild-type controls

N • BMDMs transfected with interferon stimulatory DNA (ISD) or cGAMP (the activating ligand of STING1) show normal induction of Ifnb1 mRNA levels relative to similarly treated wild-type BMDMs