Phenotypes associated with this allele

• Allele Symbol: Krit1^{tm1.1(KOMP)Vlcg}
• Allele Name: targeted mutation 1.1, Velocigene
• Allele ID: MGI:5583067
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krit1^tm1.1(KOMP)Vlcg/Krit1^tm1.1(KOMP)Vlcg	C57BL/6N-Krit1^tm1.1(KOMP)Vlcg/Ucd	MGI:5631257
ht2	Krit1^tm1.1(KOMP)Vlcg/Krit1^+	C57BL/6N-Krit1^tm1.1(KOMP)Vlcg/Ucd	MGI:5767706

Genotype
MGI:5631257

hm1

• Allelic Composition: Krit1^{tm1.1(KOMP)Vlcg}/Krit1^{tm1.1(KOMP)Vlcg}
• Genetic Background: C57BL/6N-Krit1^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 14555A-F11

Data Sources

IMPC Data for Krit1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:211773 )

IMPC - UCD

abnormal heart morphology ( J:211773 )

IMPC - UCD

abnormal heart looping ( J:211773 )

IMPC - UCD

abnormal pericardium morphology ( J:211773 )

IMPC - UCD

craniofacial

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - UCD

embryo

abnormal pharyngeal arch morphology ( J:211773 )

IMPC - UCD

abnormal embryo turning ( J:211773 )

IMPC - UCD

abnormal left-right axis patterning ( J:211773 )

IMPC - UCD

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal embryo size ( J:211773 )

IMPC - UCD

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

IMPC - UCD

abnormal somite shape ( J:211773 )

IMPC - UCD

abnormal allantois morphology ( J:211773 )

IMPC - UCD

abnormal chorioallantoic fusion ( J:211773 )

IMPC - UCD

growth/size/body

embryonic growth retardation ( J:211773 )

IMPC - UCD

abnormal embryo size ( J:211773 )

IMPC - UCD

hearing/vestibular/ear

abnormal otic vesicle morphology ( J:211773 )

IMPC - UCD

integument

pallor ( J:211773 )

IMPC - UCD

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - UCD

preweaning lethality, complete penetrance ( J:211773 )

IMPC - UCD

nervous system

abnormal neural tube morphology ( J:211773 )

IMPC - UCD

abnormal neural tube closure ( J:211773 )

IMPC - UCD

vision/eye

abnormal optic vesicle formation ( J:211773 )

IMPC - UCD

Genotype
MGI:5767706

ht2

• Allelic Composition: Krit1^{tm1.1(KOMP)Vlcg}/Krit1⁺
• Genetic Background: C57BL/6N-Krit1^{tm1.1(KOMP)Vlcg}/Ucd
• Cell Lines: 14555A-F11

Data Sources

IMPC Data for Krit1

behavior/neurological

decreased grip strength ( J:211773 )

♂

IMPC - UCD

cardiovascular system

abnormal heart morphology ( J:211773 )

♀

IMPC - UCD

enlarged heart ( J:211773 )

♀

IMPC - UCD

growth/size/body

enlarged heart ( J:211773 )

♀

IMPC - UCD

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - UCD

nervous system

absent optic nerve ( J:211773 )

♀

IMPC - UCD

vision/eye

abnormal eye morphology ( J:211773 )

♀

IMPC - UCD

absent optic nerve ( J:211773 )

♀

IMPC - UCD