Phenotypes associated with this allele

• Allele Symbol: Clec4n^tm1.2Mgne
• Allele Name: targeted mutation 1.2, Mihai G Netea
• Allele ID: MGI:5582826
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec4n^tm1.2Mgne/Clec4n^tm1.2Mgne	involves: C57BL/6 * C57BL/6J	MGI:5582831

Genotype
MGI:5582831

hm1

• Allelic Composition: Clec4n^tm1.2Mgne/Clec4n^tm1.2Mgne
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal neutrophil physiology ( J:209284 )

• neutrophils exhibit less efficient in phagocytosing and killing C. glabrata ex vivo with reduced reactive oxygen species production compared with wild-type cells

• however, reactive oxygen species production stimulated with PMA is normal

impaired neutrophil phagocytosis ( J:209284 )

• of C. glabrata ex vivo

abnormal macrophage physiology ( J:209284 )

• peritoneal macrophages exhibit less efficient uptake and killing of C. glabrata ex vivo compared with wild-type cells

impaired macrophage phagocytosis ( J:209284 )

• of C. glabrata ex vivo

abnormal chemokine secretion ( J:209284 )

• decreased Cxcl1 (KC) secretion from peritoneal macrophages stimulated with heat killed C. albicans hyphae

abnormal interferon secretion ( J:209284 )

decreased interferon-gamma secretion ( J:209284 )

• from splenocytes re-stimulated ex vivo with heat killed C. glabrata or C. albicans yeast following systemic C. glabrata infection

increased interferon-gamma secretion ( J:209284 )

• from splenocytes stimulated with heat killed C. albicans hyphae

abnormal interleukin secretion ( J:209284 )

increased interleukin-1 alpha secretion ( J:209284 )

• from peritoneal macrophages stimulated with heat killed C. albicans hyphae

increased interleukin-1 beta secretion ( J:209284 )

• from peritoneal macrophages stimulated with heat killed C. albicans yeast

decreased interleukin-17 secretion ( J:209284 )

• from splenocytes re-stimulated ex vivo with heat killed C. glabrata or C. albicans yeast following systemic C. glabrata infection

increased interleukin-17 secretion ( J:209284 )

• from splenocytes stimulated with heat killed C. albicans hyphae

increased interleukin-6 secretion ( J:209284 )

• from peritoneal macrophages stimulated with heat killed C. glabrata

abnormal tumor necrosis factor secretion ( J:209284 )

decreased tumor necrosis factor secretion ( J:209284 )

• from macrophages or splenocytes re-stimulated ex vivo with heat killed C. glabrata or C. albicans yeast following systemic C. glabrata infection

increased tumor necrosis factor secretion ( J:209284 )

• from peritoneal macrophages stimulated with heat killed C. glabrata or C. albicans yeast

abnormal susceptibility to fungal infection ( J:209284 )

• mice are less susceptible to C. glabrata than C. albicans with no mortality 28 days after intravenous infection

increased susceptibility to fungal infection ( J:209284 )

• mice infected with Candida glabrata exhibit higher loads and increased number of inflammatory foci partially associated with the fungi in the kidneys compared to in wild-type mice

• however, fungi load in the liver is normal

hematopoietic system

abnormal neutrophil physiology ( J:209284 )

• neutrophils exhibit less efficient in phagocytosing and killing C. glabrata ex vivo with reduced reactive oxygen species production compared with wild-type cells

• however, reactive oxygen species production stimulated with PMA is normal

impaired neutrophil phagocytosis ( J:209284 )

• of C. glabrata ex vivo

abnormal macrophage physiology ( J:209284 )

• peritoneal macrophages exhibit less efficient uptake and killing of C. glabrata ex vivo compared with wild-type cells

impaired macrophage phagocytosis ( J:209284 )

• of C. glabrata ex vivo

cellular

impaired macrophage phagocytosis ( J:209284 )

• of C. glabrata ex vivo

impaired neutrophil phagocytosis ( J:209284 )

• of C. glabrata ex vivo