Phenotypes associated with this allele

• Allele Symbol: Epcam^tm1.2Msiv
• Allele Name: targeted mutation 1.2, Mamata Sivagnanam
• Allele ID: MGI:5582762
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epcam^tm1.2Msiv/Epcam^tm1.2Msiv	involves: C57BL/6 * FVB/N * SJL	MGI:5582765

Genotype
MGI:5582765

hm1

• Allelic Composition: Epcam^tm1.2Msiv/Epcam^tm1.2Msiv
• Genetic Background: involves: C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:210901 )

• mice die within 5 to 7 days of birth

digestive/alimentary system

abnormal intestine morphology ( J:210901 )

• short length

• intestinal desmosomes exhibit sporadic irregularity with crowding and lengthening of the desmosomes compared with in wild-type mice

• however, villous structure is normal at E17 and E19 and goblet cells are normal

abnormal duodenum morphology ( J:210901 )

• postnatally mice exhibit progressive changes with abnormal invaginations between enterocytes (at P2), blunting of the intestinal villi (at P4), tufted villi (at P4), edema (at P4), crowding of enterocytes (at P4) and inflammatory infiltrate (at P4) compared with wild-type mice

abnormal ileum morphology ( J:210901 )

• postnatally mice exhibit progressive changes with abnormal invaginations between enterocytes (at P2), blunting of the intestinal villi (at P4), tufted villi (at P4), edema (at P4), crowding of enterocytes (at P4) and inflammatory infiltrate (at P4) compared with wild-type mice

abnormal jejunum morphology ( J:210901 )

• postnatally mice exhibit progressive changes with abnormal invaginations between enterocytes (at P2), blunting of the intestinal villi (at P4), tufted villi (at P4), edema (at P4), crowding of enterocytes (at P4) and inflammatory infiltrate (at P4) compared with wild-type mice

blunted small intestinal villi ( J:210901 )

• blunting and tufting at P4

intestinal edema ( J:210901 )

• at P4

abnormal intestine physiology ( J:210901 )

• permeability defects

abnormal enterocyte physiology ( J:210901 )

• enhanced migration and proliferation

abnormal enterocyte proliferation ( J:210901 )

• enhanced

small intestinal inflammation ( J:210901 )

• at P4

growth/size/body

decreased body size ( J:210901 )

• at P3

postnatal growth retardation ( J:210901 )

• mice exhibit little to no weight gain

behavior/neurological

behavior/neurological phenotype ( J:210901 )

N • mice exhibit normal gastric milk content

lethargy ( J:210901 )

• at P3

homeostasis/metabolism

intestinal edema ( J:210901 )

• at P4

immune system

small intestinal inflammation ( J:210901 )

• at P4

cellular

abnormal enterocyte proliferation ( J:210901 )

• enhanced