About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mafbtm1.1Good
targeted mutation 1.1, Lisa Goodrich
MGI:5581666
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mafbtm1.1Good/Mafbtm1.1Good involves: 129S4/SvJae * C57BL/6 * SJL MGI:5581684
cn2
 		Mafbtm1.1Good/Mafbtm1Jeng
Foxg1tm1(cre)Skm/Foxg1+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:5581686
cn3
 		Mafbtm1.1Good/Mafbtm1Jeng
Tg(Neurog1-cre)1Jejo/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL MGI:5581687


Genotype
MGI:5581684
hm1
Allelic
Composition		 Mafbtm1.1Good/Mafbtm1.1Good
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1.1Good mutation (0 available); any Mafb mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:207904 )
• mice are fertile and viable with normal hearing and no gross anatomical defects




Genotype
MGI:5581686
cn2
Allelic
Composition		 Mafbtm1.1Good/Mafbtm1Jeng
Foxg1tm1(cre)Skm/Foxg1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (31 available)
Mafbtm1.1Good mutation (0 available); any Mafb mutation (22 available)
Mafbtm1Jeng mutation (0 available); any Mafb mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

respiratory system
apnea ( J:207904 )
• central apnea

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:207904 )
N
• inner ear develops normally

nervous system
nervous system phenotype ( J:207904 )
N
• spiral ganglion neuron neurite organization is normal




Genotype
MGI:5581687
cn3
Allelic
Composition		 Mafbtm1.1Good/Mafbtm1Jeng
Tg(Neurog1-cre)1Jejo/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1.1Good mutation (0 available); any Mafb mutation (22 available)
Mafbtm1Jeng mutation (0 available); any Mafb mutation (22 available)
Tg(Neurog1-cre)1Jejo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:207904 )
N
• mice survive through adulthood

nervous system
nervous system phenotype ( J:207904 )
N
• spiral ganglion neuron (SGN) processes organization and density are normal
• efferent innervation of cochlea is normal
• SGN firing properties are normal
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• some are abnormally small or misshapen
• reduced numbers at P15
abnormal cochlear ganglion morphology ( J:207904 )
• failure of post-synpatic differentiation near the basolateral pole of the inner hair cells by P6
• impaired presynaptic development

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:207904 )
N
• distortion product otoacoustic emissions are normal
abnormal inner hair cell synaptic ribbon morphology ( J:207904 )
• some are abnormally small or misshapen
• reduced numbers at P15
increased or absent threshold for auditory brainstem response ( J:207904 )
• dampened auditory brainstem response (ABR) waveforms and elevated auditory thresholds
• ABR wave I is delayed with increased latency compared to in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory