About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Xktm1Ariv
targeted mutation 1, Alicia Rivera
MGI:5581658
Summary 4 genotypes


Genotype
MGI:5581720
hm1
Allelic
Composition
Xktm1Ariv/Xktm1Ariv
Genetic
Background
B6.Cg-Xktm1Ariv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xktm1Ariv mutation (0 available); any Xk mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• no obvious pathology in younger mice
• occasional muscle fiber splitting
• occasional angulated atrophic fibers
• occasional diffusely basophilic sarcoplasm
• occasional regenerating muscle fibers in exercising mice
• variation in muscle fiber size in older mice
• frequent internalized nuclei

nervous system
• giant axons found in sciatic nerve and anterior column of spinal cord
• number of giant axons increases in older mice
• giant axons filled with irregularly bundled neurofilaments
• clusters of microtubules, dense lamellar bodies, and membranous structures
• myelin sheaths irregular over internodes of giant axons with extended gaps
• myelin sheaths of giant axons thinner than expected
• some small nerve fibers with thicker myelin sheaths than expected




Genotype
MGI:5581674
cx2
Allelic
Composition
Keltm1Slee/Keltm1Slee
Xktm1Ariv/Y
Genetic
Background
B6.Cg-Keltm1Slee Xktm1Ariv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Keltm1Slee mutation (0 available); any Kel mutation (33 available)
Xktm1Ariv mutation (0 available); any Xk mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 3.2-fold increase in Ca2+ ion content
• small but significant increase
• significantly increased
• modest increase in reticulocyte level (2.71 to 3.6 %)

homeostasis/metabolism
• small but significant increase




Genotype
MGI:5581719
cx3
Allelic
Composition
Keltm1Slee/Keltm1Slee
Xktm1Ariv/Xktm1Ariv
Genetic
Background
B6.Cg-Keltm1Slee Xktm1Ariv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Keltm1Slee mutation (0 available); any Kel mutation (33 available)
Xktm1Ariv mutation (0 available); any Xk mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• giant axons found in sciatic nerve and anterior column of spinal cord
• number of giant axons increases in older mice
• giant axons filled with irregularly bundled neurofilaments
• clusters of microtubules, dense lamellar bodies, and membranous structures
• myelin sheaths irregular over internodes of giant axons with extended gaps
• myelin sheaths of giant axons thinner than expected
• some small nerve fibers with thicker myelin sheaths than expected

muscle
N
• no obvious pathology in younger mice
• occasional muscle fiber splitting
• occasional angulated atrophic fibers
• occasional diffusely basophilic sarcoplasm
• variation in muscle fiber size in older mice
• frequent internalized nuclei




Genotype
MGI:5581673
ot4
Allelic
Composition
Xktm1Ariv/Y
Genetic
Background
B6.Cg-Xktm1Ariv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xktm1Ariv mutation (0 available); any Xk mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 2.7-fold increase in Ca2+ ion content
• small but significant increase

homeostasis/metabolism





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
01/17/2023
MGI 6.22
The Jackson Laboratory