Phenotypes associated with this allele

• Allele Symbol: Cables1^{Tg(CAG-rtTA,CAG-tTS)138Utr}
• Allele Name: transgene insertion 138, University of Tsukuba Laboratory Animal Resource Center
• Allele ID: MGI:5581467
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cables1^Tg(CAG-rtTA,CAG-tTS)138Utr/Cables1^Tg(CAG-rtTA,CAG-tTS)138Utr	CAJcl.Cg-Cables1^Tg(CAG-rtTA,CAG-tTS)138Utr	MGI:5581638
ht2	Cables1^Tg(CAG-rtTA,CAG-tTS)138Utr/Cables1^+	CAJcl.Cg-Cables1^Tg(CAG-rtTA,CAG-tTS)138Utr	MGI:5581639

Genotype
MGI:5581638

hm1

• Allelic Composition: Cables1^{Tg(CAG-rtTA,CAG-tTS)138Utr}/Cables1^{Tg(CAG-rtTA,CAG-tTS)138Utr}
• Genetic Background: CAJcl.Cg-Cables1^{Tg(CAG-rtTA,CAG-tTS)138Utr}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal CNS glial cell morphology ( J:167073 )

• disruption of the dorsal midline zipper glia (MZG) but not of the ventral MZG in forebrains at E18.5

absent corpus callosum ( J:167073 )

• agenesis in all homozygous mice, which was accompanied by the formation of Probst bundles

cellular

abnormal CNS glial cell morphology ( J:167073 )

• disruption of the dorsal midline zipper glia (MZG) but not of the ventral MZG in forebrains at E18.5

Genotype
MGI:5581639

ht2

• Allelic Composition: Cables1^{Tg(CAG-rtTA,CAG-tTS)138Utr}/Cables1⁺
• Genetic Background: CAJcl.Cg-Cables1^{Tg(CAG-rtTA,CAG-tTS)138Utr}

behavior/neurological

circling ( J:167073 )

nervous system

decreased hippocampal commissure size ( J:167073 )

decreased anterior commissure size ( J:167073 )

abnormal forebrain morphology ( J:167073 )

• abnormalities are reported in the medial position, including the limbic system, but not elsewhere in the forebrain

enlarged lateral ventricles ( J:167073 )

absent corpus callosum ( J:167073 )

• agenesis in half of the heterozygous mice, which was accompanied by the formation of Probst bundles