All Phenotypes Slc39a5<tm1.1Gka> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc39a5^tm1.1Gka
targeted mutation 1.1, Glen K Andrews
MGI:5581453

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc39a5^tm1.1Gka/Slc39a5^tm1.1Gka	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5581457

Allelic Composition	Slc39a5^tm1.1Gka/Slc39a5^tm1.1Gka
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a5^tm1.1Gka mutation (0 available); any Slc39a5 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal zinc homeostasis ( J:209760 )

• mice fed excess zinc fail to exhibit an increase in pancreas zinc levels unlike wild-type mice

• mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

abnormal liver zinc level ( J:209760 )

• increased

endocrine/exocrine glands

pancreatic acinar cell atrophy ( J:209760 )

• in mice exposed to zinc

increased susceptibility to induced pancreatitis ( J:209760 )

• mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

liver/biliary system

abnormal liver zinc level ( J:209760 )

• increased

immune system

increased susceptibility to induced pancreatitis ( J:209760 )

• mice exhibit increased susceptibility to zinc-induced pancreatitis compared with control mice

digestive/alimentary system

pancreatic acinar cell atrophy ( J:209760 )

• in mice exposed to zinc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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