Phenotypes associated with this allele

• Allele Symbol: Grid2^ho-18J
• Allele Name: hotfoot 18 Jackson
• Allele ID: MGI:5578544
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grid2^ho-18J/Grid2^ho-18J	B6.Cg-Grid2^ho-18J/GrsrJ	MGI:5578564

Genotype
MGI:5578564

hm1

• Allelic Composition: Grid2^ho-18J/Grid2^ho-18J
• Genetic Background: B6.Cg-Grid2^ho-18J/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

ataxia ( J:212310 )

• homozygotes have a staggering gait with hesitant placement of the feet, similar to that seen in other hotfoot mutants

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:212310 )

• auditory brainstem response assessment of one homozygote and one sibling control at 107 days of age showed that the homozygote was deaf

reproductive system

male infertility ( J:212310 )

♂ • homozygous males do not reproduce, but sperm from homozygous males can be successfully used in in vitro fertilization to generate viable offspring