Phenotypes associated with this allele

• Allele Symbol: Acadvl^tm1Zkhu
• Allele Name: targeted mutation 1, Zaza Khuchua
• Allele ID: MGI:5578174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acadvl^tm1Zkhu/Acadvl^tm1Zkhu Tg(Myh6-cre)1Jmk/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr	MGI:5578180

Genotype
MGI:5578180

cn1

• Allelic Composition: Acadvl^tm1Zkhu/Acadvl^tm1Zkhu; Tg(Myh6-cre)1Jmk/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:208711 )

• in mice exposed to combined stresses of cold and fasting at 2 months

cardiovascular system

abnormal heart morphology ( J:208711 )

• abnormal heart histology at 6 months

• decreased heart ATP content at baseline and with high workload in response to dobutamine challenge

abnormal myocardial fiber morphology ( J:208711 )

• frequent vacuolations

• however, cardiomyocytes exhibit normal fat accumulation and mitochondrial ultrastructure and oxidative function

increased heart weight ( J:208711 )

• at 6 months

abnormal heart left ventricle morphology ( J:208711 )

• increased left ventricular end-diastolic and end-systolic dimensions at 6, but not 3, months

dilated heart left ventricle ( J:208711 )

• at 6, but not 3, months

abnormal cardiovascular system physiology ( J:208711 )

• isolated hearts exhibit reduced systolic and diastolic function compared with control hearts

dilated cardiomyopathy ( J:208711 )

• at 6 months

decreased ventricle muscle contractility ( J:208711 )

• decreased left ventricular fractional shortening at 6 months

decreased heart rate ( J:208711 )

• severe in cold-exposed fasted mice

• however, rewarming rescues and recovers heart rate and function

homeostasis/metabolism

abnormal adaptive thermogenesis ( J:208711 )

• cold-exposed fasted mice exhibit lethargy, increased lethality, reduced respiratory exchange ratio, decreased body temperature, decreased circulating glucose and decreased heart rate and function compared with control mice

decreased circulating glucose level ( J:208711 )

• after 60 minutes of cold exposure and fasting

• however, glucose levels are normal prior to cold exposure

decreased core body temperature ( J:208711 )

• after 45 minutes of cold exposure and fasting

• however, body temperature prior to cold exposure is normal

decreased respiratory quotient ( J:208711 )

• in cold-exposed fasted mice

behavior/neurological

lethargy ( J:208711 )

• in 6 month old mice exposed to cold and fasting

muscle

abnormal myocardial fiber morphology ( J:208711 )

• frequent vacuolations

• however, cardiomyocytes exhibit normal fat accumulation and mitochondrial ultrastructure and oxidative function

dilated cardiomyopathy ( J:208711 )

• at 6 months

decreased ventricle muscle contractility ( J:208711 )

• decreased left ventricular fractional shortening at 6 months

growth/size/body

increased heart weight ( J:208711 )

• at 6 months