Phenotypes associated with this allele

• Allele Symbol: Cir1^{tm3a(KOMP)Wtsi}
• Allele Name: targeted mutation 3a, Wellcome Trust Sanger Institute
• Allele ID: MGI:5577261
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cir1^tm3a(KOMP)Wtsi/Cir1^tm3a(KOMP)Wtsi	C57BL/6N-Cir1^tm3a(KOMP)Wtsi/Wtsi	MGI:5883877

Genotype
MGI:5883877

hm1

• Allelic Composition: Cir1^{tm3a(KOMP)Wtsi}/Cir1^{tm3a(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Cir1^{tm3a(KOMP)Wtsi}/Wtsi
• Cell Lines: BEPD0009_1_E01

Data Sources

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

persistent trigeminal artery ( J:239583 )

DMDD

absent intracranial segment of vertebral artery ( J:239583 )

DMDD

additional anastomosis between intracranial vertebral arteries ( J:239583 )

DMDD

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

abnormal atrioventricular cushion morphology ( J:239583 )

DMDD

overriding aortic valve ( J:239583 )

DMDD

perimembraneous ventricular septal defect ( J:239583 )

DMDD

abnormal pulmonary valve cusp morphology ( J:239583 )

DMDD

craniofacial

occipital bone foramen ( J:239583 )

DMDD

digestive/alimentary system

abnormal large intestine morphology ( J:239583 )

DMDD

embryo

abnormal Mullerian duct morphology ( J:239583 )

DMDD

abnormal Wolffian duct morphology ( J:239583 )

DMDD

abnormal placenta morphology ( J:261316 )

• reduced cellular density of placenta at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

endocrine/exocrine glands

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

abnormal thyroid gland morphology ( J:239583 )

DMDD

growth/size/body

heterochrony ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:261316 )

• lethality at P14, with viable fetuses at E14.5

muscle

abnormal eye muscle morphology ( J:239583 )

DMDD

nervous system

abnormal forebrain morphology ( J:239583 )

DMDD

multiple persisting craniopharyngeal ducts ( J:239583 )

DMDD

abnormal hypoglossal nerve topology ( J:239583 )

DMDD

renal/urinary system

small kidney ( J:239583 )

DMDD

abnormal ureter morphology ( J:239583 )

DMDD

skeleton

occipital bone foramen ( J:239583 )

DMDD

absent costovertebral joint ( J:239583 )

DMDD

decreased rib number ( J:239583 )

DMDD

rib bifurcation ( J:239583 )

DMDD

rib fusion ( J:239583 )

DMDD

scoliosis ( J:239583 )

DMDD

decreased cervical vertebrae number ( J:239583 )

DMDD

absent vertebral pedicles ( J:239583 )

DMDD

fusion of vertebral arches ( J:239583 )

DMDD

vision/eye

abnormal eye muscle morphology ( J:239583 )

DMDD

abnormal optic cup morphology ( J:239583 )

DMDD