Analysis Tools
behavior/neurological
head tossing
(
J:229303
)
|
• this phenotype ranges from mild to severe
|
endocrine/exocrine glands
 |
• histology of 2 males at 10 months of age found testicular atrophy
|
growth/size/body
hearing/vestibular/ear
|
• moderate to severe hearing loss wsa found by ABR as early as five-and-a-half weeks of age, the earliest timepoint assessed
|
|
• histology found otitis media in all ears assessed from 6 weeks to 6 months of age
|
immune system
|
• histology found otitis media in all ears assessed from 6 weeks to 6 months of age
|
integument
|
• the fur, most noticeably on the rump, can grow in reverse orientation leading to an overall ruffled coat appearance
|
ruffled hair
(
J:229303
)
limbs/digits/tail
curly tail
(
J:229303
)
mortality/aging
|
• heterozygous intercrosses generate on average less than 21% affected progeny, indicative of some death in utero
|
nervous system
hydrocephaly
(
J:229303
)
|
• mild hydrocephalus found by histology of one 4-month-old and one 6-month-old
|
reproductive system
|
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• histology of 2 males at 10 months of age found testicular atrophy
|
|
• homozygotes seldom breed, but they do have a normal lifespan
|
