All Phenotypes Tg(n-TRtct5)609Slac MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(n-TRtct5)609Slac
transgene insertion 609, Susan L Ackerman
MGI:5576567

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gtpbp2^nmf205/Gtpbp2^nmf205 Tg(n-TRtct5)609Slac/0	C57BL/6J-Gtpbp2^nmf205 Tg(n-TRtct5)609Slac	MGI:5577075

Allelic Composition	Gtpbp2^nmf205/Gtpbp2^nmf205 Tg(n-TRtct5)609Slac/0
Genetic Background	C57BL/6J-Gtpbp2^nmf205 Tg(n-TRtct5)609Slac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2^nmf205 mutation (1 available); any Gtpbp2 mutation (37 available)
Tg(n-TRtct5)609Slac mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:211326 )

• although the cerebellum is not identical to Gtpbp2 wild-type controls, this transgene, which has brain-specific expression of wild-type n-Tr20, rescues most of the nmf205 mutant phenotype such that at 6 months of age the neuronal death is greatly attenuated in the brain and retina

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