Phenotypes associated with this allele

• Allele Symbol: Xbp1^tm1.2Geno
• Allele Name: targeted mutation 1.2, Genoway
• Allele ID: MGI:5576516
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xbp1^tm1.2Geno/Xbp1^tm1.2Geno	involves: 129S2/SvPas * C57BL/6	MGI:5576525

Genotype
MGI:5576525

hm1

• Allelic Composition: Xbp1^tm1.2Geno/Xbp1^tm1.2Geno
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:211440 )

• mice die by E13.5

growth/size/body

embryonic growth retardation ( J:211440 )

decreased embryo weight ( J:211440 )

• at E12.5

cellular

decreased cell proliferation ( J:211440 )

• cultured E10.5 embryonic cells exhibit reduced cell proliferation and are not responsive to VEGF treatment unlike wild-type cells

integument

pallor ( J:211440 )

• in embryos

cardiovascular system

abnormal blood vessel morphology ( J:211440 )

• fewer blood vessels in embryos

embryo

embryonic growth retardation ( J:211440 )

decreased embryo weight ( J:211440 )

• at E12.5