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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zfp335blt
blood T cells low
MGI:5576210
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zfp335blt/Zfp335blt involves: C57BL/6 MGI:5604146
cx2
 		Rag1tm1(GFP)Imku/?
Zfp335blt/Zfp335blt 		involves: C57BL/6 * CBA MGI:5604147


Genotype
MGI:5604146
hm1
Allelic
Composition		 Zfp335blt/Zfp335blt
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zfp335blt mutation (1 available); any Zfp335 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:214793 )
• impaired maturation in single positive thymocytes and recent thymic emigrant (RTE) naive T cells
abnormal CD4-positive T cell differentiation ( J:214793 )
• decrease in mature single positive T cell turnover as assessed by BrdU+ incorporation
• impaired accumulation of SP cells with a mature CD62Lhi Cd24lo phenotype in mice treated with FTY720, an inhibitor of thymic egress
abnormal CD8-positive, alpha-beta T cell differentiation ( J:214793 )
• impaired accumulation of SP cells with a mature CD62Lhi Cd24lo phenotype in mice treated with FTY720, an inhibitor of thymic egress
decreased B cell number ( J:214793 )
• decreased numbers of splenic B cells (CD19+)
decreased CD4-positive, alpha-beta T cell number ( J:214793 )
• twofold decrease in CD4 mature single positive thymocytes
• CD4+ naive T cell numbers reduced by fivefold in the spleen
decreased CD4-positive, alpha-beta memory T cell number ( J:214793 )
• decreased numbers of CD44hi CD62Llo CD4+ T cells in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:214793 )
• twofold decrease in CD8 mature single positive thymocytes
• CD8+ naive T cell numbers reduced by eight fold in the spleen
decreased CD8-positive, alpha-beta memory T cell number ( J:214793 )
• decreased numbers of CD44hi CD62Llo CD8+ T cells in the spleen
decreased NK T cell number ( J:214793 )
• decreased numbers of invariant natural killer cells (iNKT) in the spleen
decreased regulatory T cell number ( J:214793 )
• decreased numbers of thymic and splenic CD4+ Foxp3+ cells
decreased single-positive T cell number ( J:214793 )
• decreased numbers of single positive thymocytes, especially CD62Lhi Cd24lo, in secondary lymphoid organs

immune system
abnormal T cell differentiation ( J:214793 )
• impaired maturation in single positive thymocytes and recent thymic emigrant (RTE) naive T cells
abnormal CD4-positive T cell differentiation ( J:214793 )
• decrease in mature single positive T cell turnover as assessed by BrdU+ incorporation
• impaired accumulation of SP cells with a mature CD62Lhi Cd24lo phenotype in mice treated with FTY720, an inhibitor of thymic egress
abnormal CD8-positive, alpha-beta T cell differentiation ( J:214793 )
• impaired accumulation of SP cells with a mature CD62Lhi Cd24lo phenotype in mice treated with FTY720, an inhibitor of thymic egress
decreased B cell number ( J:214793 )
• decreased numbers of splenic B cells (CD19+)
decreased CD4-positive, alpha-beta T cell number ( J:214793 )
• twofold decrease in CD4 mature single positive thymocytes
• CD4+ naive T cell numbers reduced by fivefold in the spleen
decreased CD4-positive, alpha-beta memory T cell number ( J:214793 )
• decreased numbers of CD44hi CD62Llo CD4+ T cells in the spleen
decreased CD8-positive, alpha-beta T cell number ( J:214793 )
• twofold decrease in CD8 mature single positive thymocytes
• CD8+ naive T cell numbers reduced by eight fold in the spleen
decreased CD8-positive, alpha-beta memory T cell number ( J:214793 )
• decreased numbers of CD44hi CD62Llo CD8+ T cells in the spleen
decreased NK T cell number ( J:214793 )
• decreased numbers of invariant natural killer cells (iNKT) in the spleen
decreased regulatory T cell number ( J:214793 )
• decreased numbers of thymic and splenic CD4+ Foxp3+ cells
decreased single-positive T cell number ( J:214793 )
• decreased numbers of single positive thymocytes, especially CD62Lhi Cd24lo, in secondary lymphoid organs




Genotype
MGI:5604147
cx2
Allelic
Composition		 Rag1tm1(GFP)Imku/?
Zfp335blt/Zfp335blt
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1tm1(GFP)Imku mutation (0 available); any Rag1 mutation (120 available)
Zfp335blt mutation (1 available); any Zfp335 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive T cell differentiation ( J:214793 )
• high rate of decay of recent thymic emigrants (RTE) in spleen and lymph nodes as compared to heterozygous controls, suggesting a block in post-thymic naive T cell maturation

immune system
abnormal CD4-positive T cell differentiation ( J:214793 )
• high rate of decay of recent thymic emigrants (RTE) in spleen and lymph nodes as compared to heterozygous controls, suggesting a block in post-thymic naive T cell maturation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory