Phenotypes associated with this allele

• Allele Symbol: Tg(Cd68-BCL2)526Medz
• Allele Name: transgene insertion 526, Ruslan Medzhitov
• Allele ID: MGI:5575881
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Cd68-BCL2)526Medz/0	involves: 129 * C57BL/6	MGI:5575886

Genotype
MGI:5575886

tg1

• Allelic Composition: Tg(Cd68-BCL2)526Medz/0
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased apoptosis ( J:82809 )

• myeloid cells of transgenic mice are resistant to apoptotic stimuli

immune system

abnormal immune cell physiology ( J:82809 )

• myeloid cells of transgenic mice are resistant to apoptotic stimuli

increased inflammatory response ( J:82809 )

• hemizygous transgenic mice exhibit a heightened inflammatory response

reproductive system

reduced female fertility ( J:82809 )

• female mice hemizygous for this transgene exhibit very low fertility, so all breeding of the line has employed wild-type females and hemizygous transgenic males