Phenotypes associated with this allele

• Allele Symbol: Errfi1^tm3.1Gvw
• Allele Name: targeted mutation 3.1, George F Vande Woude
• Allele ID: MGI:5575860
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0	involves: 129 * 129S4/SvJaeSor * BALB/cJ	MGI:5575863
cn2	Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA	MGI:5575862

Genotype
MGI:5575863

cn1

• Allelic Composition: Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw; Tg(CMV-cre)1Cgn/0
• Genetic Background: involves: 129 * 129S4/SvJaeSor * BALB/cJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Osteoarthritis-like disorder in Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0 knee joints

mortality/aging

premature death ( J:206807 )

• most die by 6 months of age

skeleton

osteoarthritis ( J:206807 )

• develop an osteoarthritis like phenotype in multiple synovial joints including the knee, ankle and temporal-mandibular joint

abnormal joint morphology ( J:206807 )

• ankles show extensive changes including swelling, stiffness, osteophytes

joint swelling ( J:206807 )

• in ankles

abnormal articular cartilage morphology ( J:206807 )

• in knee joints of 3.6 months old animals

• osteophytes in knee joints of 3 months to 1 year old animals

immune system

osteoarthritis ( J:206807 )

• develop an osteoarthritis like phenotype in multiple synovial joints including the knee, ankle and temporal-mandibular joint

homeostasis/metabolism

joint swelling ( J:206807 )

• in ankles

Genotype
MGI:5575862

cn2

• Allelic Composition: Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw; Tg(Col2a1-cre)1Asz/0
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * CBA

Osteoarthritis-like phenotype in Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(Col2a1-cre)1Asz/0 and Errfi1^tm3.1Gvw/Errfi1^tm3.1Gvw Tg(CMV-cre)1Cgn/0 mice

skeleton

joint swelling ( J:206807 )

• subchondral cyst formation in knee joints of 3 months to 1 year old animals but rarely affected the ankle and temporal-mandibular joint.

osteoarthritis ( J:206807 )

• in knee joints of 3 months to 1 year old animals but rarely affecting the ankle or temporal-mandibular joints, even after 15 months of age

abnormal femur morphology ( J:206807 )

• two- to three-fold higher chondrocyte number in femur

increased chondrocyte number ( J:206807 )

• two- to three-fold higher in femurs and tibias

abnormal articular cartilage morphology ( J:206807 )

• in knee joints of 3 months to 1 year old animals but rarely in the ankle even after 15 months of age

• thickening, especially at older age at 15.3 months

• more collagen II is present

• osteophytes in knee joints of 3 months to 1 year old animals

abnormal endochondral bone ossification ( J:206807 )

• formation of osteophytes in the knee joints of 3 months to 1 year old animals

immune system

osteoarthritis ( J:206807 )

• in knee joints of 3 months to 1 year old animals but rarely affecting the ankle or temporal-mandibular joints, even after 15 months of age

limbs/digits/tail

abnormal femur morphology ( J:206807 )

• two- to three-fold higher chondrocyte number in femur

homeostasis/metabolism

joint swelling ( J:206807 )

• subchondral cyst formation in knee joints of 3 months to 1 year old animals but rarely affected the ankle and temporal-mandibular joint.