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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gins4tm1Ntak
targeted mutation 1, Nobuyuki Takakura
MGI:5575557
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gins4tm1Ntak/Gins4tm1Ntak involves: 129P2/OlaHsd * C57BL/6 MGI:5575562
cx2
 		Gins4tm1Ntak/Gins4+
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0 		involves: 129P2/OlaHsd * C3H * C57BL/6 MGI:5575638


Genotype
MGI:5575562
hm1
Allelic
Composition		 Gins4tm1Ntak/Gins4tm1Ntak
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gins4tm1Ntak mutation (0 available); any Gins4 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:209708 )
• embryos elicit hemorrhage in the decidua and die soon after implantation

cellular
increased inner cell mass apoptosis ( J:209708 )
• day 4 of blastocyst culture
decreased inner cell mass proliferation ( J:209708 )
• in blastocysts in culture

embryo
increased inner cell mass apoptosis ( J:209708 )
• day 4 of blastocyst culture
decreased inner cell mass proliferation ( J:209708 )
• in blastocysts in culture




Genotype
MGI:5575638
cx2
Allelic
Composition		 Gins4tm1Ntak/Gins4+
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0
Tg(Krt19-Wnt1)2Maos/0
Genetic
Background		 involves: 129P2/OlaHsd * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gins4tm1Ntak mutation (0 available); any Gins4 mutation (12 available)
Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko mutation (0 available)
Tg(Krt19-Wnt1)2Maos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:209708 )
• as measured by weight of the stomachs and tumor




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory