All Phenotypes Gtpbp2<tm1Ynim> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gtpbp2^tm1Ynim
targeted mutation 1, Yasuharu Nishimura
MGI:5575491

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gtpbp2^tm1Ynim/Gtpbp2^tm1Ynim n-TRtct5^m1J/n-TRtct5^m1J	B6.Cg-Gtpbp2^tm1Ynim	MGI:5581421
cx2	Gtpbp2^nmf205/Gtpbp2^tm1Ynim n-TRtct5^m1J/n-TRtct5^m1J	(C57BL/6J-Gtpbp2^nmf205/J x B6.Cg-Gtpbp2^tm1Ynim)F1	MGI:5581408

Allelic Composition	Gtpbp2^tm1Ynim/Gtpbp2^tm1Ynim n-TRtct5^m1J/n-TRtct5^m1J
Genetic Background	B6.Cg-Gtpbp2^tm1Ynim

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2^tm1Ynim mutation (0 available); any Gtpbp2 mutation (37 available)
n-TRtct5^m1J mutation (4 available); any n-TRtct5 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:211326 )

abnormal cerebellum morphology ( J:211326 )

abnormal cerebellar layer morphology ( J:211326 )

• similar diminution of the cerebellum at 2 months of age is found as is found in nmf205 homozygotes and compound heterozygotes

neurodegeneration ( J:211326 )

cellular

increased neuron apoptosis ( J:211326 )

Allelic Composition	Gtpbp2^nmf205/Gtpbp2^tm1Ynim n-TRtct5^m1J/n-TRtct5^m1J
Genetic Background	(C57BL/6J-Gtpbp2^nmf205/J x B6.Cg-Gtpbp2^tm1Ynim)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gtpbp2^nmf205 mutation (1 available); any Gtpbp2 mutation (37 available)
Gtpbp2^tm1Ynim mutation (0 available); any Gtpbp2 mutation (37 available)
n-TRtct5^m1J mutation (4 available); any n-TRtct5 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellum morphology ( J:211326 )

• the progressive neuronal apoptosis that results in smaller cerebellum, hippocampus CA2 region, dentate gyrus, and degeneration in the retina of nmf205 homozygotes is also found in this compound heterozygote

neurodegeneration ( J:211326 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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