About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dlx2tm1.1Rth
targeted mutation 1.1, David H Rowitch
MGI:5575409
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1tm1Rth
Dlx2tm1.1Rth/Dlx2tm1.1Rth 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5698611
cn2
 		Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1+
Dlx2tm1.1Rth/Dlx2+ 		involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5698612


Genotype
MGI:5698611
cn1
Allelic
Composition		 Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1tm1Rth
Dlx2tm1.1Rth/Dlx2tm1.1Rth
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1tm1Rth mutation (1 available); any Dlx1 mutation (21 available)
Dlx2tm1.1Rth mutation (1 available); any Dlx2 mutation (25 available)
Olig1tm1(cre)Rth mutation (1 available); any Olig1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, incomplete penetrance ( J:212992 )
• mice fail to thrive and tend to die in the neonatal period
postnatal lethality, complete penetrance ( J:212992 )
• mice are always dead before 21 days of age




Genotype
MGI:5698612
cn2
Allelic
Composition		 Olig1tm1(cre)Rth/Olig1tm1(cre)Rth
Dlx1tm1Rth/Dlx1+
Dlx2tm1.1Rth/Dlx2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlx1tm1Rth mutation (1 available); any Dlx1 mutation (21 available)
Dlx2tm1.1Rth mutation (1 available); any Dlx2 mutation (25 available)
Olig1tm1(cre)Rth mutation (1 available); any Olig1 mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:212992 )
N
• mice survive to adulthood

nervous system
nervous system phenotype ( J:212992 )
N
• interneuron numbers tend to be more normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory