About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Themism1Btlr
mutation 1, Bruce Beutler
MGI:5575394
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Themism1Btlr/Themism1Btlr C57BL/6J-Themism1Btlr MGI:5575396


Genotype
MGI:5575396
hm1
Allelic
Composition		 Themism1Btlr/Themism1Btlr
Genetic
Background		 C57BL/6J-Themism1Btlr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Themism1Btlr mutation (1 available); any Themis mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:211400 )
N
• mice exhibit normal immune response to NP-Ficoll
abnormal lymphocyte morphology ( J:211400 )
• increase in B to T cell ratio
decreased B-1a cell number ( J:211400 )
• decreased frequency
decreased CD4-positive, alpha-beta T cell number ( J:211400 )
• a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells
impaired humoral immune response ( J:211400 )
• in response to ovalbumin administered with aluminum hydroxide
• however, response to Semliki Forest virus is normal

hematopoietic system
abnormal lymphocyte morphology ( J:211400 )
• increase in B to T cell ratio
decreased B-1a cell number ( J:211400 )
• decreased frequency
decreased CD4-positive, alpha-beta T cell number ( J:211400 )
• a decrease in the CD4+ to CD8+ T cell ratio caused by a diminished frequency of CD4+ T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory