Phenotypes associated with this allele

• Allele Symbol: Adcy3^Jll
• Allele Name: Jll
• Allele ID: MGI:5574448
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adcy3^Jll/Adcy3^Jll	involves: 129S1/SvImJ * C57BL/6J	MGI:5575782
ht2	Adcy3^Jll/Adcy3^+	C57BL/6J-Adcy3^Jll	MGI:5575779
ht3	Adcy3^Jll/Adcy3^+	involves: 129S1/SvImJ * C57BL/6J	MGI:5575781

Genotype
MGI:5575782

hm1

• Allelic Composition: Adcy3^Jll/Adcy3^Jll
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:223554 )

• after 8 weeks on high fat diet as compared to wild-type

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:223554 )

growth/size/body

decreased body weight ( J:223554 )

• after 8 weeks on high fat diet as compared to wild-type

decreased susceptibility to diet-induced obesity ( J:223554 )

Genotype
MGI:5575779

ht2

• Allelic Composition: Adcy3^Jll/Adcy3⁺
• Genetic Background: C57BL/6J-Adcy3^Jll

adipose tissue

decreased total body fat amount ( J:223554 , J:223554 )

• observed in males and females after 12 weeks on high fat diet as compared to wild-type (J:223554)

• failure to increase fat mass is progressive; increasing to 10 fold by 12 weeks (J:223554)

• difference in fat mass is observed in gonadal and inguinal fat pads (J:223554)

♂ • observed in males after 8 weeks on high fat diet as compared to wild-type (J:223554)

decreased brown fat cell size ( J:223554 )

• reduced adipocyte area in interscapular BAT after 12 weeks on high fat diet as compared to wild-type

decreased white fat cell size ( J:223554 )

• reduced adipocyte area in WAT (gonadal and inguinal) after 12 weeks on high fat diet as compared to wild-type

decreased percent body fat/body weight ( J:223554 )

• after 24 weeks on high fat diet as compared to wild-type

growth/size/body

decreased body weight ( J:223554 , J:223554 )

• observed in males and females after 12 weeks on high fat diet as compared to wild-type (J:223554)

• gain in lean mass is similar to wild-type (J:223554)

♂ • observed in males after 8 weeks on high fat diet as compared to wild-type (J:223554)

decreased susceptibility to diet-induced obesity ( J:223554 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:223554 )

liver/biliary system

decreased susceptibility to diet-induced hepatic steatosis ( J:223554 )

• after 12 weeks on high fat diet as compared to wild-type

Genotype
MGI:5575781

ht3

• Allelic Composition: Adcy3^Jll/Adcy3⁺
• Genetic Background: involves: 129S1/SvImJ * C57BL/6J

adipose tissue

decreased total body fat amount ( J:223554 )

• after 8 weeks on high fat diet as compared to wild-type

decreased percent body fat/body weight ( J:223554 )

• after 8 weeks on high fat diet as compared to wild-type

behavior/neurological

hyperactivity ( J:223554 )

♂ • increased activity in dark phase is observed in chow-fed males

growth/size/body

decreased body weight ( J:223554 )

• after 8 weeks on high fat diet as compared to wild-type

decreased susceptibility to diet-induced obesity ( J:223554 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:223554 )

decreased circulating glucose level ( J:223554 )

♂ • in fasting 3 month old male mice

decreased circulating insulin level ( J:223554 )

• in fasting 3 month old mice

decreased circulating leptin level ( J:223554 )

• in fasting 3 month old mice

• leptin level is decreased 5 fold in males and 3 fold in females as compared to wild-type

increased oxygen consumption ( J:223554 )

♂ • increased VO₂ in dark phase is observed in chow-fed males