All Phenotypes Hprt1<tm1(CAG-NRIP1)Vcls> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hprt1^{tm1(CAG-NRIP1)Vcls}
targeted mutation 1, Vincent Cavailles
MGI:5574440

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hprt1^{tm1(CAG-NRIP1)Vcls}/Hprt1⁺	involves: 129 * C57BL/6	MGI:5574443
ot2	Hprt1^{tm1(CAG-NRIP1)Vcls}/Y	involves: 129 * C57BL/6	MGI:5574444

Allelic Composition	Hprt1^{tm1(CAG-NRIP1)Vcls}/Hprt1⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-NRIP1)Vcls} mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased enterocyte apoptosis ( J:211324 )

• 2-fold decrease in apoptotic cells

abnormal enterocyte proliferation ( J:211324 )

• 3.7-fold decrease in cells synthesizing DNA compared with wild-type mice

abnormal small intestine morphology ( J:211324 )

• crypt to villus axis is decreased compared to in wild-type mice

• longer intestine compared with wild-type mice

• however, total surface area of intestinal epithelium is normal

abnormal Paneth cell morphology ( J:211324 )

• decreased differentiation

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:211324 )

• decreased differentiation

cellular

decreased enterocyte apoptosis ( J:211324 )

• 2-fold decrease in apoptotic cells

abnormal enterocyte proliferation ( J:211324 )

• 3.7-fold decrease in cells synthesizing DNA compared with wild-type mice

Allelic Composition	Hprt1^{tm1(CAG-NRIP1)Vcls}/Y
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-NRIP1)Vcls} mutation (0 available); any Hprt1 mutation (1274 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased enterocyte apoptosis ( J:211324 )

• 2-fold decrease in apoptotic cells

abnormal enterocyte proliferation ( J:211324 )

• 3.7-fold decrease in cells synthesizing DNA compared with wild-type mice

abnormal small intestine morphology ( J:211324 )

• crypt to villus axis is decreased compared to in wild-type mice

• longer intestine compared with wild-type mice

• however, total surface area of intestinal epithelium is normal

abnormal Paneth cell morphology ( J:211324 )

• decreased differentiation

endocrine/exocrine glands

abnormal Paneth cell morphology ( J:211324 )

• decreased differentiation

cellular

decreased enterocyte apoptosis ( J:211324 )

• 2-fold decrease in apoptotic cells

abnormal enterocyte proliferation ( J:211324 )

• 3.7-fold decrease in cells synthesizing DNA compared with wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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