Analysis Tools
mortality/aging
| N |
• mice are viable
|
vision/eye
| N |
• normal Mueller glia and amacrine cell numbers at P30
|
|
• disorganized in some mice
|
|
• in some mice
|
|
• in some mice
• bilateral in 2 of 30 mice
|
|
• rosette-like structures in some mice
|
|
• in mice older than 10 months
• however, numbers at P30 are normal
|
|
• in the outer nuclear layer at P30
|
|
• reduced red/green sensitive cones in most of the retina at P30 and in mice older than P300
|
|
• reduced numbers at P30
|
|
• reduced numbers in the inner nuclear layer
|
|
• festooned in some mice
|
|
• at P14 and progressively worse with age
|
|
• at P30
|
anophthalmia
(
J:207121
)
|
• in some mice
• bilateral in 2 of 30 mice
|
|
• undetectable at P30
|
|
• reduced b-wave under scotopic conditions at P30
• reduced a-wave under scotopic conditions at P60
• increased a-wave and b-wave latency at P60 under scotopic conditions
|
|
• mice fail to respond in a visual acuity test
|
nervous system
| N |
• mice exhibit normal head development
|
|
• in mice older than 10 months
• however, numbers at P30 are normal
|
|
• in the outer nuclear layer at P30
|
|
• reduced red/green sensitive cones in most of the retina at P30 and in mice older than P300
|
|
• reduced numbers at P30
|
|
• reduced numbers in the inner nuclear layer
|
|
• disorganized in some mice
|
pigmentation
|
• festooned in some mice
|
