All Phenotypes Rapgef4<tm1.2Chen> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rapgef4^tm1.2Chen
targeted mutation 1.2, Ju Chen
MGI:5571845

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rapgef4^tm1.2Chen/Rapgef4^tm1.2Chen	involves: 129 * Black Swiss * C57BL/6 * SJL	MGI:5571873
cx2	Rapgef3^tm1.2Chen/Rapgef3^tm1.2Chen Rapgef4^tm1.2Chen/Rapgef4^tm1.2Chen	involves: 129 * Black Swiss * C57BL/6 * SJL	MGI:5571874

Allelic Composition	Rapgef4^tm1.2Chen/Rapgef4^tm1.2Chen
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef4^tm1.2Chen mutation (1 available); any Rapgef4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:210426 )

N	• mice exhibit normal baseline cardiac function and response to transverse aortic constriction

ventricular tachycardia ( J:210426 )

• reduced tendency to ventricular tachycardia after a burst pacing protocol compared with wild-type mice

• however, mice exhibit normal heart rate, ECG parameters and refractory periods at baseline or in response to isoproterenol

muscle

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished prior to or after isoproterenol treatment

cellular

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished prior to or after isoproterenol treatment

Allelic Composition	Rapgef3^tm1.2Chen/Rapgef3^tm1.2Chen Rapgef4^tm1.2Chen/Rapgef4^tm1.2Chen
Genetic Background	involves: 129 * Black Swiss * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rapgef3^tm1.2Chen mutation (0 available); any Rapgef3 mutation (49 available)
Rapgef4^tm1.2Chen mutation (1 available); any Rapgef4 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:210426 )

N	• mice exhibit normal baseline cardiac function and response to transverse aortic constriction

muscle

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished

cellular

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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