Phenotypes associated with this allele

• Allele Symbol: Tex101^tm1Qzh
• Allele Name: targeted mutation 1, Qi Zhou
• Allele ID: MGI:5571379
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tex101^tm1Qzh/Tex101^tm1Qzh	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)	MGI:5571380

Genotype
MGI:5571380

hm1

• Allelic Composition: Tex101^tm1Qzh/Tex101^tm1Qzh
• Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * ICR)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

impaired sperm migration in female genital tract ( J:208737 )

♂ • sperm are unable to pass through the uterotubal junction of the female genital tract

♂ • sperm fail to attach to the surface of cells in the female genital tract

male infertility ( J:208737 )

♂ • despite normal mating ability, male mice do not produce offspring

decreased fertilization frequency ( J:208737 )

♂ • in vitro, sperm fertilize oocytes at a lower rate than wild-type sperm

♂ • fertilization occurs in 4 of 12 mice following 24-in tubal insemination

impaired binding of sperm to zona pellucida ( J:208737 )

♂ • sperm exhibit defective zona pellucida binding

cellular

impaired sperm migration in female genital tract ( J:208737 )

♂ • sperm are unable to pass through the uterotubal junction of the female genital tract

♂ • sperm fail to attach to the surface of cells in the female genital tract