Phenotypes associated with this allele

• Allele Symbol: Runx2^tm1.1Yyon
• Allele Name: targeted mutation 1.1, Yukio Yoneda
• Allele ID: MGI:5570536
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Runx2^tm1.1Yyon/Runx2^tm1.1Yyon Tg(Col2a1-cre)1Star/0	involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj	MGI:5570667
cn2	Runx2^tm1.1Yyon/Runx2^tm1.1Yyon Tg(Col1a1-cre)1Kry/0	involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N	MGI:5570666

Genotype
MGI:5570667

cn1

• Allelic Composition: Runx2^tm1.1Yyon/Runx2^tm1.1Yyon; Tg(Col2a1-cre)1Star/0
• Genetic Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:210124 )

• due to difficulty breathing

skeleton

delayed bone ossification ( J:210124 )

• almost complete absence of mineralized tissue at E15.5

• however, ossification of the facial bone, skull bone and clavicle is normal

delayed endochondral bone ossification ( J:210124 )

• in newborn mice, including long bones and vertebrae

respiratory system

respiratory distress ( J:210124 )

• difficulty breathing at birth leading to death

Genotype
MGI:5570666

cn2

• Allelic Composition: Runx2^tm1.1Yyon/Runx2^tm1.1Yyon; Tg(Col1a1-cre)1Kry/0
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj * FVB/N

mortality/aging

mortality/aging ( J:210124 )

N • mice are produced in normal Mendelian ratio

skeleton

skeleton phenotype ( J:210124 )

N • mice exhibit normal skeletal development