Phenotypes associated with this allele

• Allele Symbol: Tg(TG-SV40)#Cled
• Allele Name: transgene insertion, Catherine Ledent
• Allele ID: MGI:5569755
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(TG-SV40)#Cled/0	involves: C57BL/6J * DBA/2J	MGI:5897861

Genotype
MGI:5897861

tg1

• Allelic Composition: Tg(TG-SV40)#Cled/0
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:209788 )

• time of death ranges from as early as 9 days of age to over 22 weeks

• mice treated with T4 show a regression of symptoms after a 4-5 day delay, with disappearance of stridor and the return of normal weight, however, after an asymptomatic period of 33 days on average, dyspnea reappears progressively and mice die rapidly

endocrine/exocrine glands

thymus hypoplasia ( J:209788 )

• thymus is frequently hypoplastic

enlarged thyroid gland ( J:209788 )

• enlargement of the thyroid which compresses both the trachea and the esophagus

• thyroid is already enlarged at 1 day after birth and mice develop a goiter

thyroid gland cyst ( J:209788 )

• thyroid surface of older mice frequently shows large nodules and hemorrhagic cysts

increased thyroid carcinoma incidence ( J:209788 )

• despite continuous T4 treatment, mice develop moderately to poorly differentiated thyroid adenocarcinomas, with persistence of cell polarity and the presence of microfollicles between the densely packed cells resembling anaplastic thyroid tumors

• thyroids exhibit dedifferentiation and disorganization, rapidly followed by the development of numerous tumor nodules

decreased activity of thyroid gland ( J:209788 )

• mice are hypothyroid

iodide oxidation defect ( J:209788 )

• organification of iodide is reduced

• however, iodine uptake is maintained in proportion to the gland weight

growth/size/body

prominent forehead ( J:209788 )

• short bulging forehead

short forehead ( J:209788 )

• short bulging forehead

thyroid gland cyst ( J:209788 )

• thyroid surface of older mice frequently shows large nodules and hemorrhagic cysts

cachexia ( J:209788 )

• mice develop progressive cachexia due to reduced food intake because of compression of the trachea and esophagus by enlarged thyroid

postnatal growth retardation ( J:209788 )

• growth delay

hematopoietic system

thymus hypoplasia ( J:209788 )

• thymus is frequently hypoplastic

spleen hypoplasia ( J:209788 )

• spleen is frequently hypoplastic

homeostasis/metabolism

decreased circulating thyroxine level ( J:209788 )

immune system

thymus hypoplasia ( J:209788 )

• thymus is frequently hypoplastic

spleen hypoplasia ( J:209788 )

• spleen is frequently hypoplastic

craniofacial

prominent forehead ( J:209788 )

• short bulging forehead

short forehead ( J:209788 )

• short bulging forehead

neoplasm

increased thyroid carcinoma incidence ( J:209788 )

• despite continuous T4 treatment, mice develop moderately to poorly differentiated thyroid adenocarcinomas, with persistence of cell polarity and the presence of microfollicles between the densely packed cells resembling anaplastic thyroid tumors

• thyroids exhibit dedifferentiation and disorganization, rapidly followed by the development of numerous tumor nodules

increased metastatic potential ( J:209788 )

• thyroid tumors metastasize into the trachea, skeletal muscle, and lung

respiratory system

abnormal tracheal ciliated epithelium morphology ( J:209788 )

• the epithelium of the trachea appears pluristratified, indicating chronic irritation

respiratory distress ( J:209788 )

• mice develop dyspnea and inspiratory stridor

respiratory failure ( J:209788 )

• compression of the trachea and esophagus due to enlarged thyroid gland, accompanied by dyspnea, inspiratory stridor and dysphagia, lead to progressive cachexia and premature death