All Phenotypes Dmd<tm1.1Know> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dmd^tm1.1Know
targeted mutation 1.1, Kirk Knowlton
MGI:5569634

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dmd^tm1.1Know/Dmd^tm1.1Know	involves: C3H	MGI:5569639
cn2	Dmd^tm1.1Know/Dmd^tm1.1Know A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ Tg(Myh6-2A)#Know/0	involves: BALB/c * C3H * C57BL/6 * FVB/N	MGI:5569640

Allelic Composition	Dmd^tm1.1Know/Dmd^tm1.1Know
Genetic Background	involves: C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^tm1.1Know mutation (0 available); any Dmd mutation (153 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Decreased susceptibility to coxsackievirus B3 viral infection of the heart in Dmd^tm1.1Know/Dmd^tm1.1Know mice

immune system

myocarditis ( J:207775 )

• less severe in mice infected with coxsackierivurs B3 than control mice

decreased susceptibility to Picornaviridae infection ( J:207775 )

• mice infected with coxsackierivurs B3 (CVB3) exhibit reduced disruption of sarcolemmal integrity, dystrophic calcification, myocarditis and viral titer in the heart compared with wild-type mice

• however, mice exhibit normal mortality, cardiac function and viral titers in the liver and pancreas

cardiovascular system

myocarditis ( J:207775 )

• less severe in mice infected with coxsackierivurs B3 than control mice

muscle

abnormal sarcolemma morphology ( J:207775 )

• mice infected with coxsackierivurs B3 (CVB3) exhibit reduced disruption of sarcolemmal integrity compared with wild-type mice

Allelic Composition	Dmd^tm1.1Know/Dmd^tm1.1Know A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺ Tg(Myh6-2A)#Know/0
Genetic Background	involves: BALB/c * C3H * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A1cf^{Tg(Myh6-cre/Esr1*)1Jmk} mutation (5 available); any A1cf mutation (39 available)
Dmd^tm1.1Know mutation (0 available); any Dmd mutation (153 available)
Tg(Myh6-2A)#Know mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Inhibition of dilated cardiomyopathy in Dmd^tm1.1Know/Dmd^tm1.1Know Tg(Myh6-2A)#Know/0 A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/0 mice

cardiovascular system

cardiac fibrosis ( J:207775 )

• less severe fibrosis in tamoxifen-treated mice

increased cardiac muscle contractility ( J:207775 )

• improved cardiac function in tamoxifen-treated mice

abnormal heart echocardiography feature ( J:207775 )

• improved cardiac function in tamoxifen-treated mice

cardiomyopathy ( J:207775 )

• less severe cardiomyopathy in tamoxifen-treated mice

homeostasis/metabolism

decreased susceptibility to injury ( J:207775 )

• tamoxifen-treated mice exhibit less severe cardiomyopathy, cardiac fibrosis and improved cardiac function compared with control mice

muscle

increased cardiac muscle contractility ( J:207775 )

• improved cardiac function in tamoxifen-treated mice

cardiomyopathy ( J:207775 )

• less severe cardiomyopathy in tamoxifen-treated mice

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