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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kmotm1.2Pjmi
targeted mutation 1.2, Paul J Muchowski
MGI:5569396
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kmotm1.2Pjmi/Kmotm1.2Pjmi FVB.B6(Cg)-Kmotm1.2Pjmi MGI:5569405


Genotype
MGI:5569405
hm1
Allelic
Composition		 Kmotm1.2Pjmi/Kmotm1.2Pjmi
Genetic
Background		 FVB.B6(Cg)-Kmotm1.2Pjmi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmotm1.2Pjmi mutation (0 available); any Kmo mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal homeostasis ( J:207199 )
• mice exhibit altered levels of several tryptophan metabolites
decreased brain enzyme/coenzyme activity ( J:207199 )
• lack of kynurenine 3-monooxygenase activity in the brain
decreased liver enzyme/coenzyme activity ( J:207199 )
• lack of kynurenine 3-monooxygenase activity in the liver

liver/biliary system
decreased liver enzyme/coenzyme activity ( J:207199 )
• lack of kynurenine 3-monooxygenase activity in the liver

nervous system
decreased brain enzyme/coenzyme activity ( J:207199 )
• lack of kynurenine 3-monooxygenase activity in the brain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/07/2026
MGI 6.24 		The Jackson Laboratory