All Phenotypes Gys2<tm1.1Arte> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gys2^tm1.1Arte/Gys2^tm1.1Arte	Not Specified	MGI:5568699
ht2	Gys2^tm1.1Arte/Gys2⁺	Not Specified	MGI:5568698

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:208923 )

• increased glucose oxidation

• hepatocytes exhibit altered glucose flux favoring lipogenesis

• during euglycemic-hyperinsulinemic clamp, mice exhibit reduced rate of glucose disposal and glucose clearance compared with wild-type mice

decreased circulating glucose level ( J:208923 )

• after a short fast

• however, levels are normal in fed and long fasted mice

decreased circulating insulin level ( J:208923 )

• basal levels

• however, level under euglycemic-hyperinsulinemic clamp is normal

abnormal gluconeogenesis ( J:208923 )

• impaired basal production

• however, mice exhibit normal suppression of glucose synthesis during the clamp

impaired glucose tolerance ( J:208923 )

decreased glycogen catabolism rate ( J:208923 )

• in hepatocytes stimulated with insulin or CpdA

• impaired glycogen synthesis after glucose administration or refeeding

decreased liver glycogen level ( J:208923 )

• near absence

insulin resistance ( J:208923 )

• modest during the euglycemic-hyperinsulinemic clamp

increased liver triglyceride level ( J:208923 )

• at 2 to 3 months

• at 6 months

liver/biliary system

decreased liver glycogen level ( J:208923 )

• near absence

increased liver triglyceride level ( J:208923 )

• at 2 to 3 months

• at 6 months

abnormal hepatocyte physiology ( J:208923 )

• hepatocytes exhibit altered glucose flux favoring lipogenesis

• absence of glycogen synthesis after glucose administration or refeeding

Allelic Composition	Gys2^tm1.1Arte/Gys2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gys2^tm1.1Arte mutation (0 available); any Gys2 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:208923 )

N	• mice exhibit normal whole-body insulin sensitivity

impaired glucose tolerance ( J:208923 )

decreased glycogen catabolism rate ( J:208923 )

• stimulated by CpdA

• however, insulin stimulated incorporation of labeled glucose into glycogen

increased liver triglyceride level ( J:208923 )

• at 6 months

liver/biliary system

increased liver triglyceride level ( J:208923 )

• at 6 months

abnormal hepatocyte physiology ( J:208923 )

• impaired glycogen synthesis after glucose administration or refeeding

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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