Phenotypes associated with this allele

• Allele Symbol: Crbn^tm1Csp
• Allele Name: targeted mutation 1, Chul-Seung Park
• Allele ID: MGI:5568118
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crbn^tm1Csp/Crbn^tm1Csp	B6N.Cg-Crbn^tm1Csp	MGI:5568119

Genotype
MGI:5568119

hm1

• Allelic Composition: Crbn^tm1Csp/Crbn^tm1Csp
• Genetic Background: B6N.Cg-Crbn^tm1Csp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:208570 )

• in mice fed a high fat diet

decreased circulating glucose level ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased circulating insulin level ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased circulating leptin level ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased circulating free fatty acids level ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

improved glucose tolerance ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

increased insulin sensitivity ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased liver triglyceride level ( J:208570 )

• in mice fed a high fat diet or normal chow

liver/biliary system

abnormal liver morphology ( J:208570 )

• the liver of mice fed a high fat diet is not as pale as in similarly treated wild-type mice

decreased liver triglyceride level ( J:208570 )

• in mice fed a high fat diet or normal chow

small liver ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased liver weight ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased susceptibility to diet-induced hepatic steatosis ( J:208570 )

• in mice fed a high fat diet

growth/size/body

decreased body weight ( J:208570 )

• in mice fed a high fat diet compared with similarly treated wild-type mice

decreased susceptibility to diet-induced obesity ( J:208570 )

• in mice fed a high fat diet

adipose tissue

decreased epididymal fat pad weight ( J:208570 )

♂ • in mice fed normal chow compared with similarly treated wild-type mice

♂ • 2.7-fold less at 14 weeks in mice fed a high fat diet

behavior/neurological

behavior/neurological phenotype ( J:208570 )

N • mice fed a high fat diet exhibit normal food intake