All Phenotypes Klf3<m1Cmhd> MGI Mouse

premature death ( J:206507 )

• some mice die before 60 weeks likely due to heart failure

lethality throughout fetal growth and development, incomplete penetrance ( J:206507 )

• some mice die in utero

neonatal lethality, incomplete penetrance ( J:206507 )

• some neonates breath occasionally for 30 minutes then stop breathing and die

cardiovascular system phenotype ( J:206507 )

N	• surviving adult mice exhibit normal peripheral vasculature

abnormal ascending aorta morphology ( J:206507 )

• post-stenotic enlargement of the diastolic diameter of the ascending aorta

abnormal ventricle myocardium morphology ( J:206507 )

• disorganized and thickened septal myocardium at E14.5

increased atrioventricular cushion size ( J:206507 )

• that may obstruct flow

abnormal heart left atrium morphology ( J:206507 )

• increased left atrial area

increased heart left atrium size ( J:206507 )

• in surviving adult mice

abnormal heart right atrium morphology ( J:206507 )

• increased right atrial area

increased heart right atrium size ( J:206507 )

• in surviving adult mice

atrial septal defect ( J:206507 )

• in some mice

increased heart weight ( J:206507 )

• increased relative weight in surviving adult mice

• in mice that die prematurely

cardiac hypertrophy ( J:206507 )

• ventricular hypertrophy in mice that die neonatally

• in mice that die prematurely

• eccentric hypertrophy in surviving mice

abnormal heart left ventricle morphology ( J:206507 )

• increased diastolic volume in surviving adult mice

abnormal aortic valve cusp morphology ( J:206507 )

• blebs or small hematomas in the aortic valve leaflets

• however, no aortic valve regurgitation is observed

bicuspid aortic valve ( J:206507 )

• occasional

thick aortic valve cusps ( J:206507 )

• in adult mice

• in mice that die neonatally

aortic valve stenosis ( J:206507 )

• partially fused leaflets

abnormal blood flow velocity ( J:206507 )

• high aortic blood velocity in 6 of 7 mice at 8 weeks

• increased aortic blood velocity in 136 of 584 mice

• increased peak blood velocity in the main pulmonary artery and at the atrioventricular valves during early venctricular filling (E-wave)

• E-wave fusion with the arterial filling wave (A-wave) occur significantly more often in the left or right filling waveforms

• surviving adult mice exhibit improved diastolic filling with an increase in early filling (E-wave) velocity for left and right atrioventricular filling

• Background Sensitivity: more prevalent in mice on a higher C57BL/6 compared with mice on a background containing BALB/cJ

• however, peak inflow velocities during atrial contraction or in heart rate

hypervolemia ( J:206507 )

• in surviving adult mice

increased cardiac output ( J:206507 )

• doubled in surviving adult mice

hematoma ( J:206507 )

• blebs or small hematomas in the aortic valve leaflets

abnormal blood pressure regulation ( J:206507 )

• reduced aortic systolic and diastolic blood pressure

• however, ventricular systolic blood pressure is normal

increased cardiac muscle contractility ( J:206507 )

• in surviving adult mice

decreased systemic arterial blood pressure ( J:206507 )

• surviving adult mice

decreased mean systemic arterial blood pressure ( J:206507 )

hypotension ( J:206507 )

• arterial in surviving adult mice

congestive heart failure ( J:206507 )

• some mice die before 60 weeks likely due to heart failure

increased spleen weight ( J:206507 )

• increased relative weight in surviving adult mice

anemia ( J:206507 )

• slightly in surviving adult mice

decreased erythrocyte cell number ( J:206507 )

• in surviving adult mice

decreased hemoglobin content ( J:206507 )

• in surviving adult mice

reticulocytosis ( J:206507 )

increased heart weight ( J:206507 )

• increased relative weight in surviving adult mice

• in mice that die prematurely

cardiac hypertrophy ( J:206507 )

• ventricular hypertrophy in mice that die neonatally

• in mice that die prematurely

• eccentric hypertrophy in surviving mice

decreased body weight ( J:206507 )

• in surviving adult mice at 10 to 11 weeks

increased kidney weight ( J:206507 )

• increased relative weight in surviving adult mice

increased spleen weight ( J:206507 )

• increased relative weight in surviving adult mice

increased oxygen consumption ( J:206507 )

• in surviving adult mice

abnormal ventricle myocardium morphology ( J:206507 )

• disorganized and thickened septal myocardium at E14.5

increased cardiac muscle contractility ( J:206507 )

• in surviving adult mice

decreased abdominal fat pad weight ( J:206507 )

• in surviving adult mice at 18 to 25 weeks

decreased percent body fat/body weight ( J:206507 )

• in young adult mice

increased spleen weight ( J:206507 )

• increased relative weight in surviving adult mice

increased brain weight ( J:206507 )

• increased relative weight in surviving adult mice

increased kidney weight ( J:206507 )

• increased relative weight in surviving adult mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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