Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm2Arbr mutation
(1 available);
any
Mapt mutation
(428 available)
Shox2tm1.1(cre)Oki mutation
(0 available);
any
Shox2 mutation
(19 available)
Slc17a6tm1.1Thna mutation
(0 available);
any
Slc17a6 mutation
(59 available)
Slc17a6tm1.2Edw mutation
(0 available);
any
Slc17a6 mutation
(59 available)
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nervous system
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• frequencies of locomotor activity induced in isolated spinal cords increase with increasing NMDA concentrations, but are significantly lower than those observed in control spinal cords
• locomotor burst duration increases but duty cycle is not changed in mutant preparations (increased interburst interval)
• coefficients of variation of main locomotor parameters (cycle period, burst duration, amplitude, duty cycle) are increased compared to controls
• spinal cords from mutants display lower drug-evoked and stimulus-evoked locomotor frequencies
• flexor-extensor coupling is not significantly changed at any locomotor frequency
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm39.1(CAG-hop/EYFP)Hze mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Shox2tm1.1(cre)Oki mutation
(0 available);
any
Shox2 mutation
(19 available)
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nervous system
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• electrical stimulation of spinal cords to induce locomotor activity is decreased by about 25% when Shox2 interneurons are inactivated by light, which is similar to the phenotype observed when the population of Shox2 interneurons is ablated
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2tm1.1(cre)Oki mutation
(0 available);
any
Shox2 mutation
(19 available)
Tg(CAG-Bgeo/GFP)21Lbe mutation
(2 available)
Vsx2tm1(DTA)Kash mutation
(0 available);
any
Vsx2 mutation
(23 available)
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nervous system
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• number of Shox2-expressing V2a interneurons is reduced by 98%; total number of Shox2-expressing interneurons is reduced by >80%
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• variability in locomotor parameters (cycle period, burst duration, amplitude) that are observed in isolated neonatal spinal cords exposed to low NMDA concentrations is increased in mutants compared to controls; higher NMDA concentrations reduce this variability
• other parameters such as burst frequency and flexor-extensor alternation are not significantly different
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Analysis Tools