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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Serpina1atm1Amgh
targeted mutation 1, A McGarry Houghton
MGI:5566806
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Serpina1atm1Amgh/Serpina1atm1Amgh involves: 129X1/SvJ MGI:5566807
ht2
 		Serpina1atm1Amgh/Serpina1a+ involves: 129X1/SvJ MGI:5566809
cn3
 		Serpina1atm1Amgh/Serpina1atm1Amgh
Tg(EIIa-cre)C5379Lmgd/0 		involves: 129X1/SvJ * FVB/N MGI:5566808


Genotype
MGI:5566807
hm1
Allelic
Composition		 Serpina1atm1Amgh/Serpina1atm1Amgh
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina1atm1Amgh mutation (0 available); any Serpina1a mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:208746 )
• no mice are produced from breeding heterozygous mice




Genotype
MGI:5566809
ht2
Allelic
Composition		 Serpina1atm1Amgh/Serpina1a+
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina1atm1Amgh mutation (0 available); any Serpina1a mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:208746 )
• mice exhibit uncompromised elastase inhibitory function and organ (heart, lung, spleen, kidney, liver, brain and gastrointestinal tract) histology




Genotype
MGI:5566808
cn3
Allelic
Composition		 Serpina1atm1Amgh/Serpina1atm1Amgh
Tg(EIIa-cre)C5379Lmgd/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Serpina1atm1Amgh mutation (0 available); any Serpina1a mutation (23 available)
Tg(EIIa-cre)C5379Lmgd mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:208746 )
• mice die prior to E8.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory