Phenotypes associated with this allele

• Allele Symbol: Cxcl5^tm1.1Mkch
• Allele Name: targeted mutation 1.1, Markus Koch
• Allele ID: MGI:5565192
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cxcl5^tm1.1Mkch/Cxcl5^tm1.1Mkch	B6.129P2-Cxcl5^tm1.1Mkch	MGI:5567831

Genotype
MGI:5567831

hm1

• Allelic Composition: Cxcl5^tm1.1Mkch/Cxcl5^tm1.1Mkch
• Genetic Background: B6.129P2-Cxcl5^tm1.1Mkch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:208901 )

• resistant to fetal tuberculosis in M. tuberculosis-infected mice

immune system

immune system phenotype ( J:208901 )

N • mice exhibit normal type 1 T cells responses

decreased neutrophil cell number ( J:208901 )

• in the lungs of M. tuberculosis-infected mice

decreased interferon-alpha secretion ( J:208901 )

• in the lungs of M. tuberculosis-infected mice

decreased interleukin-1 alpha secretion ( J:208901 )

• in the lungs of M. tuberculosis-infected mice

decreased interleukin-6 secretion ( J:208901 )

• in the lungs of M. tuberculosis-infected mice

decreased tumor necrosis factor secretion ( J:208901 )

• in the lungs of M. tuberculosis-infected mice

decreased susceptibility to bacterial infection ( J:208901 )

• mice infected with M. tuberculosis exhibit impaired polymorphonuclear leukocytes response in the lungs, decreased proinflammatory cytokines (IL6, IL1alpha, TNF and IFNgamma) in the lungs and resistance to fatal tuberculosis compared with wild-type mice

• however, mice exhibit normal numbers of alveolar macrophages, lung macrophages and lung monocytes

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:208901 )

• resistant to fetal tuberculosis in M. tuberculosis-infected mice

hematopoietic system

decreased neutrophil cell number ( J:208901 )

• in the lungs of M. tuberculosis-infected mice